Immunotherapy for prostate cancer

Current Pharmaceutical Design
R Jeffrey KarnesEugene D Kwon

Abstract

The absence of curative therapies for advanced or recurrent forms of prostate cancer has prompted a vigorous search for novel treatment strategies. Immunotherapy encompasses one particularly promising systemic approach to treat prostate cancer. Immune-based strategies to treat prostate cancer have recently been facilitated by the identification of a number of prostate tissue/tumor antigens that can be targeted, either by antibody or T cells, to promote prostate tumor cell injury or death. These same prostate antigens can also be used for the construction of vaccines to induce prostate-specific T cell-mediated immunity. Greater insight into specific mechanisms that govern antigen-specific T cell activation has brought with it a number of innovative methods to induce and enhance T cell-mediated responses against prostate tumors. For instance, autologous dendritic cells loaded with prostate antigens have proved useful to induce prostate-specific T cell activation. Similarly, in vivo manipulations of the T cell costimulatory pathway receptors can greatly facilitate tumor-specific T cell activation and potentiate T cell-mediated responses against a number of malignancies, including prostate cancer. Therefore, in this review we summa...Continue Reading

Citations

Jun 6, 2009·Cancer Immunology, Immunotherapy : CII·Vittore CeredaKwong Y Tsang
Aug 21, 2013·Cancer Immunology, Immunotherapy : CII·Monireh MohsenzadeganAhmad Shariftabrizi
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ailin BaiJianzhu Chen
Sep 6, 2007·The Journal of Clinical Investigation·Russel S TaichmanKenneth J Pienta
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Nov 15, 2012·Immunotherapy·Nick Giannoukakis, Massimo Trucco
May 19, 2010·Expert Review of Clinical Immunology·Brett PhillipsMassimo Trucco

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