Immunotherapy for prostate cancer.

Current Urology Reports
Lawrence Fong, Eric J Small

Abstract

Whereas androgen deprivation and chemotherapy have become the cornerstone of therapy for advanced prostate cancer, novel therapies are being developed that may expand upon currently available treatments. The identification of antigens expressed by prostate tissue and/or prostate cancer that are recognized by T cells or antibodies creates opportunities to develop novel immunotherapeutic approaches including tumor vaccines. Proteins expressed in prostate cancer including prostate-specific antigen, prostatic acid phosphatase, and prostate membrane antigen have been used as immunologic targets for immunotherapy. Moreover, innovations in cancer genomics and proteomics also will aid in the identification of immunologic targets. Emerging trials have demonstrated that immunotherapy may not only generate immune responses in patients, but also clinical responses. Future studies will be directed at capitalizing on these findings.

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Citations

Jan 20, 2012·Der Urologe. Ausg. A·A Heidenreich
Oct 17, 2007·Prostate Cancer and Prostatic Diseases·A R YoungerA Haque
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward Cha, Lawrence Fong
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Apr 25, 2007·The Prostate·Elena N KlyushnenkovaRichard B Alexander

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