Immunotherapy for recurrent miscarriage

The Cochrane Database of Systematic Reviews
T F PorterJ R Scott

Abstract

Because immunological aberrations might be the cause of miscarriage in some women, several immunotherapies have been used to treat women with otherwise unexplained recurrent pregnancy loss. The objective of this review was to assess the effects of any immunotherapy, including paternal leukocyte immunization and intravenous immune globulin on the live birth rate in women with previous unexplained recurrent miscarriages. We searched the Cochrane Pregnancy and Childbirth Group Trials Register (December 2005), the Cochrane Central Register of Controlled Trials (The Cochrane Library 2004, Issue 3), MEDLINE (1966 to September 2004) and EMBASE (1980 to September 2004). Randomized trials of immunotherapies used to treat women with three or more prior miscarriages and no more than one live birth after, in whom all recognised non-immunologic causes of recurrent miscarriage had been ruled out and no simultaneous treatment was given. The review author and the two co-authors independently extracted data and assessed study quality for all studies considered for this review. Twenty trials of high quality were included. The various forms of immunotherapy did not show significant differences between treatment and control groups in terms of subs...Continue Reading

Citations

Mar 13, 2009·Human Reproduction Update·Leigh R GuerinSarah A Robertson
Jun 28, 2013·BMC Medicine·Elisabeth Clare LarsenNick Macklon
Apr 24, 2016·American Journal of Reproductive Immunology : AJRI·Zhilan LiuAimin Zhao
Aug 5, 2015·Women's Health·Angena Agenor, Sohinee Bhattacharya
Jan 13, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Linda A BradleyJoan A Scott
Jan 20, 2012·Inflammopharmacology·David A Clark
Mar 13, 2014·American Journal of Reproductive Immunology : AJRI·Rocio Ramos-MedinaSilvia Sánchez-Ramón
Jul 6, 2014·The Cochrane Database of Systematic Reviews·Paulien G de JongSaskia Middeldorp
Oct 10, 2018·The Cochrane Database of Systematic Reviews·David M HaasPatrick S Ramsey
Oct 22, 2014·The Cochrane Database of Systematic Reviews·Luchin F WongJames R Scott
Nov 1, 2013·The Cochrane Database of Systematic Reviews·David M Haas, Patrick S Ramsey
Jun 27, 2014·Journal of Obstetrics and Gynaecology of India·Ashok Kumar
Jan 23, 2018·Frontiers in Medicine·Louise C Kenny, Douglas B Kell
Apr 23, 2005·The Cochrane Database of Systematic Reviews·A AlemanE Bergel
Nov 21, 2019·The Cochrane Database of Systematic Reviews·David M HaasPatrick S Ramsey
Jun 24, 2020·Biochemistry. Biokhimii︠a︡·L V KrechetovaN K Tetruashvili
May 13, 2020·American Journal of Reproductive Immunology : AJRI·Dana M SavulescuMelinda Suchard
Sep 25, 2012·Molecular Immunology·David C Kilpatrick

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