Immunotherapy for small-cell lung cancer: emerging evidence

Future Oncology
Martin ReckNiels Reinmuth

Abstract

Treatment for small-cell lung cancer (SCLC) has changed little over the past few decades; available therapies have failed to extend survival in advanced disease. In recent years, immunotherapy with treatments such as interferons, TNFs, vaccines and immune checkpoint inhibitors has advanced and shown promise in the treatment of several tumor types. Immune checkpoint inhibitors such as ipilimumab, nivolumab, pembrolizumab, durvalumab, tremelimumab and ulocuplumab are at the forefront of immunotherapy and have achieved approvals for certain cancer types, including melanoma (ipilimumab, nivolumab and pembrolizumab), non-SCLC (nivolumab and pembrolizumab) and renal cell carcinoma (nivolumab). Clinical trials are investigating different immunotherapies in patients with other solid and hematologic malignancies, including SCLC. We review emerging evidence supporting the use of immunotherapy in SCLC patients.

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT00483509
NCT01331525
NCT02239900
NCT02046733
NCT01450761
NCT01928394
NCT02538666
NCT02472977
NCT02481830
NCT02054806

Software Mentioned

IMPULSE

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