Immunotherapy for the Treatment of Uveal Melanoma: Current Status and Emerging Therapies

Current Oncology Reports
Kimberly M Komatsubara, Richard D Carvajal

Abstract

Uveal melanoma is a distinct subset of melanoma with a biology and treatment approach that is unique from that of cutaneous melanoma. Here we will review the current data evaluating immunotherapies in both the adjuvant and metastatic settings in uveal melanoma. In the adjuvant setting, interferon demonstrated no survival benefit in uveal melanoma, and studies evaluating immune-based strategies such as vaccine therapy are ongoing. Anti-CTLA-4 and anti-PD-1/ PD-L1 blockade in uveal melanoma have been evaluated in several small prospective and/or retrospective studies with rare responses and no overall survival benefit demonstrated. Ongoing studies evaluating combination checkpoint inhibition and other antibody-based therapies are ongoing. Although immunotherapy with anti-CTLA-4 and anti-PD-1 agents has dramatically changed the treatment approach to cutaneous melanoma, its success in uveal melanoma has been much more limited. Clinical trial participation should be prioritized in patients with uveal melanoma.

References

Jan 1, 1990·Cancer·P O de la CruzI W McLean
Jan 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·I de Waard-SiebingaM J Jager
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
May 9, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T KiveläS Pyrhönen
Jun 5, 2003·Melanoma Research·Agop Y BedikianSigrid Ring
Jun 26, 2003·Investigative Ophthalmology & Visual Science·Yoram CohenDavid Sidransky
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Emma KujalaTero Kivelä
Dec 24, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anette WeberAndrea Tannapfel
Jun 5, 2004·Melanoma Research·Emine KiliçAnnelies de Klein
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Leonie C van DintenPeter J van den Elsen
Jan 15, 2005·Cancer·Colleen C McLaughlinVivien W Chen
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Petra RietschelPaul B Chapman
Jun 10, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·E RichtigJ Smolle
Aug 29, 2007·Investigative Ophthalmology & Visual Science·Yang-Hwan Ryu, Jae-Chan Kim
Feb 26, 2008·Investigative Ophthalmology & Visual Science·Wanhua YangJerry Y Niederkorn
May 15, 2008·Melanoma Research·Verena VoelterSerge Leyvraz
Dec 17, 2008·Nature·Catherine D Van RaamsdonkBoris C Bastian
Jul 1, 2009·Progress in Retinal and Eye Research·Jerry Y Niederkorn
Sep 12, 2009·Ophthalmology·Anne Marie LaneEvangelos S Gragoudas
May 27, 2010·The Journal of Clinical Investigation·Jo EylesJean-Pierre Abastado
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Sep 3, 2010·Investigative Ophthalmology & Visual Science·Inge H G BronkhorstMartine J Jager
Nov 6, 2010·Science·J William HarbourAnne M Bowcock
Nov 19, 2010·The New England Journal of Medicine·Catherine D Van RaamsdonkBoris C Bastian
Dec 7, 2010·Progress in Retinal and Eye Research·Martine J JagerMichele C Madigan
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Jun 28, 2011·Ophthalmology·Arun D SinghAllan K Topham
Jul 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Avital L AmirMirjam H M Heemskerk
Aug 13, 2011·Cancer Immunology, Immunotherapy : CII·Riccardo DanielliMichele Maio
Dec 6, 2012·Melanoma Research·Muhammad Adnan KhattakJames Larkin
Jan 15, 2013·Nature Genetics·J William HarbourAnne M Bowcock
Jul 19, 2013·Cancer Discovery·Simon J FurneyRichard Marais
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Klaus G GriewankRajmohan Murali
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Sep 27, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M MaioP A Ascierto
Feb 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S LeyvrazU Keilholz

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Citations

Dec 7, 2018·Melanoma Research·Carolina CimminielloMichele Del Vecchio
Jul 6, 2019·Current Medicinal Chemistry·Snježana KaštelanKoraljka Hat
Dec 6, 2017·Current Opinion in Oncology·Vivian Chua, Andrew E Aplin
Jun 9, 2019·Cancer Immunology, Immunotherapy : CII·Ernesto RossiGiovanni Schinzari
Sep 24, 2019·International Journal of Oncology·Michael ShaughnessyHensin Tsao
Jul 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Cristina PetraliaMaria Sofia Basile
Aug 27, 2019·Current Opinion in Ophthalmology·Vivian Paraskevi DouglasDean M Cestari
Mar 3, 2018·Therapeutic Advances in Medical Oncology·Jessica YangRichard D Carvajal
Dec 21, 2018·Molecular Medicine Reports·Qiong Yi, Wen-Jin Zou
Jun 8, 2018·Journal of Surgical Oncology·Brian A BooneJames F Pingpank
Dec 5, 2020·OncoTargets and Therapy·Yu Ning ChenWen Bin Wei
Sep 30, 2019·Progress in Retinal and Eye Research·Kyra N SmitEmine Kiliҫ
Apr 11, 2021·The FEBS Journal·Janney Z WangWenying Shu
Feb 9, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Narges K TafreshiDavid L Morse
Feb 12, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justine S ParadisJ Silvio Gutkind
Aug 20, 2021·OncoTargets and Therapy·Zihan QuQinghua Zhou
Oct 31, 2021·Cardiovascular and Interventional Radiology·Rhea VeelkenFlorian van Bömmel
Nov 6, 2021·International Ophthalmology·Senmao LiLudwig M Heindl
Nov 3, 2017··Xiao LiuYao Chen

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