PMID: 9433649Jan 20, 1998Paper

Immunotherapy. I: Cytokine gene transfer strategies

Cancer Metastasis Reviews
M P Colombo, G Forni

Abstract

The cytokine approach to gene therapy of cancer stems from early studies of direct, repeated injection of recombinant cytokines at the tumor site, and extension of the bystander effect that enables a few cytokine gene transduced cells in a tumor to bring about its total destruction. This effect can be extended through the immune system, since cytokine-activated regression of a small mass of tumor cells can afford systemic protection. Transduced cells used as a vaccine provide a local concentration of both cytokine and tumor antigens. Cytokines sustain antigen uptake and presentation by increasing the immunogenic potential of the environment through the recruitment of antigen presenting cells and leukocytes, and activation of a cascade of events which amplify and tone up the efficacy of a vaccine. The promises and difficulties of this approach are discussed by considering what is still missing from experimental studies and what can best be done as soon as possible in animals and humans to reach compelling conclusions.

Citations

Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M R GrafR E Merchant
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cristiana GuiducciMario P Colombo
Aug 23, 2003·Blood·Laura BorsiLuciano Zardi
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Weixin LuIsaiah J Fidler
Sep 3, 2005·Immunological Investigations·Julie R OstbergJulie A Lanphere
Aug 11, 2000·Seminars in Cancer Biology·C S Tannenbaum, T A Hamilton

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