Immunotherapy in CNS cancers: the role of immune cell trafficking

Neuro-oncology
Nivedita M RatnamAmber J Giles

Abstract

Glioblastoma (GBM) is a highly malignant CNS tumor with very poor survival despite intervention with conventional therapeutic strategies. Although the CNS is separated from the immune system by the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier, emerging evidence of immune surveillance and the selective infiltration of GBMs by immune suppressive cells indicates that there is breakdown or compromise of these physical barriers. This in turn offers hope that immunotherapy can be applied to specifically target and reduce tumor burden. One of the major setbacks in translating immunotherapy strategies is the hostile microenvironment of the tumor that inhibits trafficking of effector immune cells such as cytotoxic T lymphocytes into the CNS. Incorporating important findings from autoimmune disorders such as multiple sclerosis to understand and thereby enhance cytotoxic lymphocyte infiltration into GBM could augment immunotherapy strategies to treat this disease. However, although these therapies are designed to evoke a potent immune response, limited space in the brain and cranial vault reduces tolerance for immune therapy-induced inflammation and resultant brain edema. Therefore, successful immunotherapy requires...Continue Reading

References

Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K E BalashovW W Hancock
Nov 24, 1999·Brain Research. Developmental Brain Research·F AlliotB Pessac
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Jun 12, 2003·Journal of Neuroimmunology·Laura HartrichMurali Ramanathan
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine E BrownMichael C Jensen
Dec 4, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marloes van ZwamLeonie A Boven
Apr 1, 2009·Nature Reviews. Clinical Oncology·Elizabeth R GerstnerTracy T Batchelor
Dec 1, 2009·Neurosurgery Clinics of North America·Ari Kane, Isaac Yang
Mar 27, 2010·International Journal of Radiation Oncology, Biology, Physics·Mackenzie C McGeeAndrew M Davidoff
May 5, 2010·The Journal of Clinical Investigation·Emma H WilsonChristopher A Hunter
May 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitsugu FujitaHideho Okada
Aug 18, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Raymond P Donnelly, Sergei V Kotenko
Nov 6, 2010·Carcinogenesis·Che LiuJeffrey K Harrison
May 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rong Rong HuangAntoni Ribas
Jun 15, 2011·Expert Review of Clinical Pharmacology·Jörg DietrichSantosh Kesari
Aug 9, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Divya SagarPooja Jain
Dec 23, 2011·Clinical & Developmental Immunology·Christopher JacksonMichael Lim
Mar 14, 2012·Immunology and Cell Biology·Nicole A de Weerd, Thao Nguyen
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jun 26, 2012·Immunological Reviews·Yukio Takeshita, Richard M Ransohoff
Dec 12, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Sameer AgnihotriGelareh Zadeh
Oct 4, 2013·Brain : a Journal of Neurology·Gilad KunisMichal Schwartz
May 16, 2014·Clinical and Experimental Immunology·C Oelkrug, J M Ramage
Jul 22, 2014·Nature·Theresa SchumacherMichael Platten
Oct 31, 2014·Neuro-oncology·Anna Sophie BerghoffWolfgang Wick
Dec 6, 2014·Cancer Research·Clare Y SlaneyPhillip K Darcy
Dec 11, 2014·Journal of Neuro-oncology·Adam M SwartzJohn H Sampson
Jan 13, 2015·Journal of Neuro-oncology·Shiao-Pei Weathers, Mark R Gilbert
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Jul 25, 2015·Nature Reviews. Immunology·E John Wherry, Makoto Kurachi
Aug 12, 2015·Nature Reviews. Neurology·Matthias PreusserJohn H Sampson
Mar 15, 2016·Frontiers in Surgery·Seyed-Mostafa RazaviGordon Li

❮ Previous
Next ❯

Citations

Apr 13, 2019·Cancers·Amber Kerstetter-FogleNicole F Steinmetz
Jul 30, 2019·Immunological Reviews·David AkhavanChristine E Brown
Jul 11, 2019·Targeted Oncology·Kunal DesaiManmeet Ahluwalia
Apr 27, 2019·Neurochemical Research·Thomas N SeyfriedPurna Mukherjee
Sep 29, 2020·Japanese Journal of Clinical Oncology·Takahide NejoHideho Okada
Aug 29, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Malte BorggreweJon D Laman
Jun 13, 2019·Oncology Letters·Thomas LinsenmannMario Löhr
Oct 12, 2019·Nature Reviews. Cancer·Costas D ArvanitisRakesh K Jain
Dec 12, 2019·Frontiers in Molecular Neuroscience·Mihaela LorgerFiona James
Dec 12, 2018·NPJ Precision Oncology·Malak AbedalthagafiKara M Foshay
Jan 6, 2021·International Journal of Molecular Sciences·Alexander OuNazanin Majd
Dec 28, 2019·Brain, Behavior, and Immunity·Annina SeilerChristopher P Fagundes
Nov 30, 2019·Pediatric Neurology·Grant A Dixon, Carlos A Pérez
Feb 28, 2021·Communications Biology·Deidre JanssonMike Dragunow
Mar 26, 2021·Neurosurgical Review·Lingnan ZhengShuang Zhang
May 28, 2021·Frontiers in Oncology·Stephen C FredericoMasaki Terabe
Jul 3, 2021·Cancers·Alice RanjanJing Wu
Jul 3, 2021·Cells·Emily E S Brettschneider, Masaki Terabe
Jul 14, 2021·Nature Reviews. Clinical Oncology·Patricia S Steeg
Jul 27, 2021·Frontiers in Aging Neuroscience·Tao LvXiaohua Zhang
Nov 1, 2018·Journal of Cellular Physiology·Masoud NajafiKeywan Mortezaee
Aug 6, 2021·British Journal of Cancer·Samuel S WidodoTheo Mantamadiotis
Jan 13, 2022·Cancer Immunology, Immunotherapy : CII·Rosy NjonkouDavid S Hersh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.