Immunotherapy in gynecological cancers: where are we?

Current Opinion in Oncology
Laura PolastroJoseph Kerger

Abstract

This manuscript discusses the clinical evidence on immunotherapy for ovarian, endometrial, and cervical cancer. We report here the results of the clinical trials and present the ongoing trial in this area. Immunotherapy has become a pillar of cancer treatment improving the prognosis of many patients with a broad variety of solid malignancies. Unfortunately, until recently the progress achieved in some other tumors has not been seen in the majority of patients with gynecological cancer. Except for some subgroups of endometrial cancers the immune checkpoint inhibitors in monotherapy have shown unsatisfactory results. However, several combinations of immunotherapy with other drugs are under investigation and are very promising. It is essential, to develop tools to select the patients who will response best to immunotherapy. Combined immune checkpoint inhibitors with targeted therapies are awaited in gynecological cancers and could provide additional benefit.

References

Jan 17, 2003·The New England Journal of Medicine·Lin ZhangGeorge Coukos
Apr 9, 2013·Critical Reviews in Oncology/hematology·Ivan Diaz-PadillaJesus Garcia-Donas
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Oct 31, 2013·Clinical Chemistry·Matthieu Le Gallo, Daphne W Bell
Apr 17, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Inge C van GoolDavid N Church
Jun 2, 2015·The New England Journal of Medicine·Dung T LeLuis A Diaz
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Junzo HamanishiIkuo Konishi
Jul 23, 2016·International Journal of Molecular Sciences·Gloria MitticaGiorgio Valabrega
Dec 3, 2016·Gynecologic Oncology Research and Practice·Stéphanie L GaillardBradley Monk
May 11, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OttJean-Charles Soria
Aug 12, 2017·Cancer Treatment Reviews·Jole VentrigliaChiara Della Pepa
Nov 3, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Sebastien FrenelAndrea Varga
Dec 19, 2017·Cancer Chemotherapy and Pharmacology·Alexander J CortezKatarzyna M Lisowska
Mar 15, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Partha BasuRobert Petit
Jul 26, 2018·Current Problems in Cancer·Jessica St LaurentSarah Feldman
Sep 29, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tara C MitchellThomas F Gajewski
Dec 7, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sanja StevanovićChristian S Hinrichs
Dec 18, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OttJared K Lunceford
Jan 30, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mary M Mullen, David G Mutch
Feb 14, 2019·Nature Reviews. Cancer·Jonathan J HavelTimothy A Chan
Apr 4, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hyun Cheol ChungAlexandra Leary
May 3, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U A MatulonisJ A Ledermann
May 18, 2019·American Society of Clinical Oncology Educational Book·Kimberly LevinsonKathleen Moore
Jun 19, 2019·International Journal of Molecular Sciences·Eleonora GhisoniGiorgio Valabrega
Aug 29, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Panagiotis A KonstantinopoulosUrsula A Matulonis
Sep 6, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R Wendel NaumannKathleen N Moore
Nov 5, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aurelien MarabelleLuis A Diaz
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U A MatulonisJ A Ledermann
Mar 14, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vicky MakkerAntonio Casado Herraez
Apr 11, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dmitriy ZamarinCarol Aghajanian

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