Immunotherapy in non-small-cell lung cancer: potential predictors of response and new strategies to assess activity

Immunotherapy
Sabrina RossiEgesta Lopci

Abstract

The treatment algorithm of advanced non-small-cell lung cancer is rapidly evolving. This result is mostly related to the availability in clinical practice of checkpoint inhibitors targeting the programmed death-1 (PD-1) and its ligands (PD-Ls) immunosuppressive pathway. Although patient's selection in the first-line setting relies essentially on high levels of PD-L1 tumor expression, treatment choice in pretreated patients is more challenging and, although clinical and biological characteristics might be of help, there is an urgent need for novel tools to better identify sensitive and resistant patients. In this context, the integration of molecular markers and immune-PET imaging might represent a potentially effective strategy to refine patient selection.

References

Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H YoungP Price
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Jun 24, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Richard L WahlMartin A Lodge
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Dec 3, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerHans J Hammers
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Aug 27, 2015·Bioconjugate Chemistry·Arutselvan NatarajanSanjiv S Gambhir
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Oct 17, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Antonio CallesPasi A Jänne
Nov 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Roy L MauteAaron M Ring
Mar 10, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Stephen HodiJedd D Wolchok
May 27, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin F GainorMari Mino-Kenudson
Aug 6, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher G EnglandWeibo Cai
Aug 31, 2016·OncoTargets and Therapy·Xin WangJinming Yu
Sep 7, 2016·World Journal of Surgical Oncology·Mitsunori HiguchiHiroyuki Suzuki
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Oct 22, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chee Khoon LeeJames Chih-Hsin Yang
Mar 2, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Arutselvan NatarajanSanjiv Sam Gambhir
Apr 1, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Steve Y ChoRichard L Wahl
Apr 1, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Katja PinkerWolfgang A Weber
Apr 9, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Annie N M WongRodney J Hicks
Jul 26, 2017·JAMA : the Journal of the American Medical Association·Carrie K Shapiro-Mendoza
Aug 18, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Sabrina RossiEgesta Lopci
Aug 23, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Kyoichi KairaTakayuki Asao

❮ Previous
Next ❯

Citations

Nov 22, 2019·Current Radiopharmaceuticals·Angelo Castello, Egesta Lopci
Oct 1, 2020·Clinical & Translational Immunology·Synat KeamAlistair M Cook
Jun 28, 2019·Nature Reviews. Clinical Oncology·Clemens GrassbergerJay S Loeffler
Feb 13, 2020·Journal of Cancer Research and Clinical Oncology·Angelo CastelloEgesta Lopci
Jul 10, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Angelo Castello, Egesta Lopci
Dec 24, 2019·Current Radiopharmaceuticals·Silvi TeloStefano Fanti
Dec 31, 2019·Current Radiopharmaceuticals·Angelo CastelloEgesta Lopci

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
transgenic

Software Mentioned

irRECIST
PERCIST
irRC

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.