Immunotherapy in small-cell lung cancer: from molecular promises to clinical challenges

Journal for Immunotherapy of Cancer
A PavanL Bonanno

Abstract

Management of small cell lung cancer (SCLC) has not changed over the last decades. In more recent years, alterations of DNA repair machinery and other molecular pathways have been identified in SCLC and preclinical data suggest that dysregulation of these pathways might offer new therapeutic opportunities.While immune checkpoint inhibitors (ICIs) have had a major impact on the clinical outcome of several solid tumors, including non-small cell lung cancer, the potential role of ICIs is currently under investigation in SCLC and some promising data are available. However, several clinical and biological hurdles have to be overcome and predictive markers are still eagerly needed. Knowledge of molecular pathways specifically involved in SCLC growth and treatment resistance is essential for a more rational planning of new combinations including ICIs.The present manuscript summarizes the current clinical evidence on immunotherapy in SCLC, describes the molecular bases underlying treatment resistance and discusses the potentialities and the rationale of different therapeutic combinations.

References

Aug 30, 1995·International Journal of Radiation Oncology, Biology, Physics·F WürschmidtH P Heilmann
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J von PawelR Gralla
Dec 19, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stein SundstrømUNKNOWN Norwegian Lung Cancer Study Group
Mar 1, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Roy M BremnesUNKNOWN Norweigian Lung Cancer Study Group
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Michael A CurranJames P Allison
Jan 3, 2014·The Journal of Clinical Investigation·Liufu DengYang-Xin Fu
Apr 17, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hélène Nagy-MignotteUNKNOWN Multidisciplinary Thoracic Oncology Group at Grenoble University Hospital, France
Jul 12, 2014·Journal of Cancer Research and Clinical Oncology·Rita de Cássia S AlvesAdriana Vial Roehe
Nov 11, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hidenobu IshiiTomoaki Hoshino
Nov 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joachim von PawelMarkus F Renschler
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
Jul 15, 2015·Nature·Julie GeorgeRoman K Thomas
Jan 3, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Andrew G NicholsonUNKNOWN Staging and Prognostic Factors Committee Advisory Boards and Participating Institutions
Jan 17, 2016·European Journal of Immunology·Alfonso R Sanchez-PauleteIgnacio Melero
Feb 5, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Roy M BremnesTom Dønnem
Jun 15, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Edurne ArriolaChristian Ottensmeier
Jul 28, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin ReckDavid Spigel
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Nov 5, 2016·Science·Ludmil B AlexandrovMichael R Stratton
Jan 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura BonannoStefano Indraccolo
Mar 3, 2017·Neurology·Paul MaddisonBethan Lang
May 24, 2017·Nature Reviews. Clinical Oncology·Joshua K SabariCharles M Rudin
Jun 6, 2017·Pharmacology & Therapeutics·Saiama N Waqar, Daniel Morgensztern
Aug 17, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OttJanice M Mehnert
Aug 17, 2017·Nature·Shom GoelJean J Zhao
Sep 9, 2017·The New England Journal of Medicine·Scott J AntoniaUNKNOWN PACIFIC Investigators
Oct 27, 2017·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Anna KretschmerThies Rösner
Oct 28, 2017·Japanese Journal of Clinical Oncology·Yoshiro NakaharaNoriyuki Masuda
Nov 25, 2017·Nature Communications·Hiro SatoAtsushi Shibata
Jan 15, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·François-Xavier DanlosOlivier Lambotte
Jan 30, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Hye Sook KimJi-Youn Han
Mar 14, 2018·British Journal of Cancer·Kent W Mouw, Panagiotis A Konstantinopoulos
Mar 15, 2018·Translational Lung Cancer Research·Triparna SenLauren Averett Byers

❮ Previous
Next ❯

Citations

Oct 22, 2020·Cancer Immunology, Immunotherapy : CII·Yeseul KimYoung Kwang Chae
Dec 9, 2020·Biotechnology and Applied Biochemistry·Soheil BehraveshHamed Mohammadi
Mar 16, 2021·Molecular Therapy Oncolytics·Anna SchwendenweinBalazs Dome
Apr 4, 2021·Seminars in Diagnostic Pathology·Jasna MetovicGiuseppe Pelosi
Jun 23, 2021·Medical Oncology·Murat Araz, Melek Karakurt Eryilmaz
Jun 19, 2021·Frontiers in Oncology·Daniel R PrincipeHidayatullah G Munshi
Jul 22, 2021·Cell Biology International·Zhenhua ZhangJunjian Wang
Aug 11, 2021·Expert Review of Respiratory Medicine·Andrea BiancoDanilo Rocco
Jun 30, 2021·Journal of the Chinese Medical Association : JCMA·Chi-Lu ChiangYuh-Min Chen
Oct 26, 2021·The Journal of International Medical Research·Chenan LiuJunmei Jia

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft
biopsies
exome sequencing

Clinical Trials Mentioned

NCT03382561
NCT02580994
NCT02934503
NCT03066778
NCT02763579
NCT03043872
NCT02402920
NCT02658214
NCT02046733
NCT03043599

Related Concepts

Related Feeds

Cancer Immunotherapy

Cancer immunotherapy is an important field of research that is looking at controlling cancer and tumor growth by activating the individuals own immune system. Recent studies have utilized chimeric antigen receptor t-cell therapy, immune checkpoint inhibitors and neoantigen vaccines. Discover the latest research on cancer immunotherapy here.