Immunotherapy in the poisoned patient. Overview of present applications and future trends
Immunotherapy for reversal of toxicity due to poisons and drugs is not new. However, refinements in antibody isolation and purification as well as the advancement of hybridoma technology and recombinant DNA biotechnology has led to a new generation of immunotherapeutic and diagnostic agents. The advent of monoclonal antibody technology in 1975 heralded the new age of immunopharmacology and immunotoxicology. Monoclonal antibodies designed for a specific antigen resolved the problem of polyclonality and cross-reactivity of traditional antibodies. Along with the production and isolation of active antibody fragments from both polyclonal and human monoclonal sources, as well as the ability to tailor-make chimeric antibodies by recombinant biotechnology, the development of novel immunotherapeutic agents has taken place. Two immunotherapeutic modalities, digoxin-specific antibody fragments (Fab) and snake antivenin, have been available for the clinician's armamentarium for years. Along the same lines of anti-digoxin Fab development, application of newer antibody isolation technology has led to a purified IgG(T) antibody for snake venom poisoning which is still in the developmental stages. Potential future developments in immunotherape...Continue Reading
Equine IgG and IgG(T) antibodies: dependence of precipitability on both antigen and antibody structure
Reversal of advanced digitoxin toxicity and modification of pharmacokinetics by specific antibodies and Fab fragments
Effects of preparatory procedures on the venom from a rattlesnake (Crotalus molossus molossus), as determined by isoelectric focusing
Capillary enzyme immunoassay field kits for the detection of snake venom in clinical specimens: a review of two years' use.
Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases
Effects of antibodies induced by a conjugate vaccine on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone absorptive transport, metabolism, and proliferation of human lung cells
A randomized multicenter trial of Crotalidae polyvalent immune F(ab) antivenom for the treatment of rattlesnake envenomation in dogs
A prospective multicenter observational study of Viperidae polyvalent immune F(ab')2 antivenom administration for the treatment of viper envenomation in dogs
Use of anti-(+)-methamphetamine monoclonal antibody to significantly alter (+)-methamphetamine and (+)-amphetamine disposition in rats
Pharmacokinetics and efficacy of digoxin specific Fab fragments in a child following massive digoxin overdose
Recombinant Adeno-Associated Virus-Mediated Expression of Methamphetamine Antibody Attenuates Methamphetamine-Induced Hyperactivity in Mice
Bioinformatics in Biomedicine
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