Immunotherapy, Inflammation and Colorectal Cancer.

Cells
Charles Robert LichtensternMichael Karin

Abstract

Colorectal cancer (CRC) is the third most common cancer type, and third highest in mortality rates among cancer-related deaths in the United States. Originating from intestinal epithelial cells in the colon and rectum, that are impacted by numerous factors including genetics, environment and chronic, lingering inflammation, CRC can be a problematic malignancy to treat when detected at advanced stages. Chemotherapeutic agents serve as the historical first line of defense in the treatment of metastatic CRC. In recent years, however, combinational treatment with targeted therapies, such as vascular endothelial growth factor, or epidermal growth factor receptor inhibitors, has proven to be quite effective in patients with specific CRC subtypes. While scientific and clinical advances have uncovered promising new treatment options, the five-year survival rate for metastatic CRC is still low at about 14%. Current research into the efficacy of immunotherapy, particularly immune checkpoint inhibitor therapy (ICI) in mismatch repair deficient and microsatellite instability high (dMMR-MSI-H) CRC tumors have shown promising results, but its use in other CRC subtypes has been either unsuccessful, or not extensively explored. This Review wil...Continue Reading

References

Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S GiacchettiF Lévi
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E HarrisM G Hanna
Jun 22, 2000·Gut·J M WheelerN J Mortensen
Jun 26, 2002·The British Journal of Surgery·A LeslieR J C Steele
May 2, 2003·Nature Reviews. Cancer·Daniel B LongleyPatrick G Johnston
Jul 29, 2003·Journal of Surgical Oncology·Yuan-Chang Chung, Ya-Fen Chang
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Jul 23, 2004·The New England Journal of Medicine·David CunninghamEric Van Cutsem
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Nov 6, 2004·Disease Markers·Jeffery W BacherStephen N Thibodeau
Jan 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PopatR S Houlston
Jul 23, 2005·Neoplasia : an International Journal for Oncology Research·Florian M CorvinusKarlheinz Friedrich
Nov 22, 2005·Gut·R JoverUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Apr 19, 2006·Cancer Research·Astrid LièvrePierre Laurent-Puig
May 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemRafael G Amado
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Apr 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto F SobreroHoward A Burris
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzJim Cassidy
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monica M BertagnolliMark Redston
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Aaron J SchetterCurtis C Harris
Oct 15, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shuji OginoCharles S Fuchs
Nov 10, 2009·International Journal of Colorectal Disease·Heike Knüpfer, Rainer Preiss
Nov 26, 2009·Gastroenterology·David P TaylorLisa A Cannon-Albright
Feb 10, 2010·Nature Reviews. Clinical Oncology·Eduardo Vilar, Stephen B Gruber
Mar 23, 2010·Lancet·David CunninghamNaureen Starling
Apr 28, 2010·Gastroenterology·Janos TerzićMichael Karin
May 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ki Y ChungLeonard B Saltz
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert de la Chapelle, Heather Hampel
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerSuzanne L Topalian
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Nov 26, 2010·Annual Review of Pathology·Eric R Fearon
Jan 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernhard MlecnikJérôme Galon
May 21, 2011·Journal of the National Cancer Institute·Frank A SinicropeDaniel J Sargent
Jun 17, 2011·Nature·Bernard KhorRamnik J Xavier
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vincent A de WegerErik Hooijberg
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton

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Citations

Jun 22, 2020·Journal of Cellular and Molecular Medicine·Jun WangJian Chen
Aug 28, 2020·Frontiers in Immunology·Izabela Sieminska, Jarek Baran
May 28, 2020·International Journal of Molecular Sciences·Eva AndreuzziMaurizio Mongiat
Dec 22, 2020·Frontiers in Pharmacology·Jia-Rong HuangZhi Shi
Nov 24, 2020·OncoTargets and Therapy·Xianzhe YuJianguo Li
Mar 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Martín S Hernández-ZazuetaArmando Burgos-Hernández
Mar 31, 2021·Clinical and Experimental Pharmacology & Physiology·Nadia A ThabetMervat M Omran
May 5, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiuli ZhaoShuo Wang
May 6, 2021·Biomaterials Science·Maria José SilveiraBruno Sarmento
Jun 3, 2021·International Journal of Molecular Sciences·Sana HibinoKoji Taniguchi
Jun 29, 2021·Frontiers in Oncology·Yongjiu DaiXiaofeng Qian
Jul 18, 2021·Journal of Cancer Research and Clinical Oncology·Nishu DalalAnil Kumar
Aug 23, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ziyu Wang, Jun Wang

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