Immunotherapy of cancer with alloreactive lymphocytes

The Lancet Oncology
S Slavin

Abstract

Immunotherapy of cancer with alloreactive lymphocytes is the mainstay of treatment, especially in haematological malignant disease. With donor lymphocyte infusion for immunotherapy, it is essential to induce host-versus-graft tolerance to ensure that the donor lymphocytes are accepted. Engraftment of haemopoietic cells of donor origin can be accomplished with reduced-intensity conditioning. Reducing transplant-related mortality by simplifing the stem-cell transplant procedure with a reduced-intensity regimen, particularly non-myeloablative conditioning, may have great potential for the treatment of malignant and non-malignant disorders.

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Citations

Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·S H KimC A Dinarello
Jan 17, 2003·Stem Cells·Julian D Down, Mary E White-Scharf
Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Myron Pollycove
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Jul 13, 2004·Experimental Hematology·Shoshana MoreckiShimon Slavin
Jan 31, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Shoshana MoreckiShimon Slavin
Mar 17, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Meirav KedmiMichael Y Shapira
Aug 30, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Shoshana MoreckiShimon Slavin
Mar 23, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GratwohlUNKNOWN Working Party on Solid Tumors
Dec 12, 2002·Bone Marrow Transplantation·A GratwohlUNKNOWN European Group for Blood and Marrow Transplantation (EBMT). Accreditation Committee
Mar 7, 2003·Bone Marrow Transplantation·A Sirvent-von BueltzingsloewenJ P Cassuto
May 17, 2003·Leukemia·A GratwohlUNKNOWN Lymphoma Working Party

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