Immunotherapy of chronic myeloid leukemia: present state and future prospects

Immunotherapy
Vladimír Vonka

Abstract

In spite of the considerable successes that have been achieved in the treatment of chronic myeloid leukemia (CML), cure for the disease can only be obtained by the present means in a rather small minority of patients. During the past decade, considerable progress has been made in the understanding of the immunology of CML, which has raised hopes that this disease may be curable by supplementing the current targeted chemotherapy with immunotherapeutic approaches. More than ten small-scale clinical trials have been carried out with experimental vaccines predominantly based on the p210bcr-abl fusion protein. Their results suggested beneficial effects in some patients. Recent data obtained in human patients as well as in animal models indicate that the p210bcr-abl protein does not carry the immunodominant epitope(s). These observations, combined with the recognition of an ever increasing number of other immunogenic proteins in CML cells, strongly support the concept that gene-modified, cell-based vaccines containing the full spectrum of tumor antigens might be the most effective immunotherapeutic approach. Recently created mathematical models have provided important leads for the timing of the combination of targeted drug therapy w...Continue Reading

References

Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Q Daley, D Baltimore
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J McLaughlinO N Witte
Feb 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R H CollinsJ Nemunaitis
May 29, 1998·The Journal of Clinical Investigation·P YotndaP Langlade-Demoyen
Sep 30, 2000·Blood Reviews·J Pinilla-IbarzD A Scheinberg
Oct 2, 2002·The Journal of Biological Chemistry·Véronique Witko-SarsatBéatrice Descamps-Latscha
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias ZeisAxel Heiser
Jun 5, 2003·Cancer Chemotherapy and Pharmacology·Masaru Minami
Jun 14, 2003·Leukemia Research·Tsuyoshi TakahashiHisamaru Hirai
Nov 25, 2003·Hematology·Helen E HeslopJeffrey J Molldrem
Jan 17, 2004·BMC Cancer·Thierry Simonart
Jul 17, 2004·Science·Neil P ShahCharles L Sawyers
Aug 19, 2004·Cancer·Rena J PasickElectra D Paskett
Sep 16, 2004·Blood·Mads Hald AndersenPer Thor Straten
Feb 16, 2005·Cancer Cell·Ellen WeisbergJames D Griffin
Feb 19, 2005·Current Oncology Reports·John S LamRobert A Figlin
Mar 31, 2005·Blood·John C Reed, Maurizio Pellecchia
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monique GannagéSophie Caillat-Zucman
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zihai LiPramod K Srivastava
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroshi FujiwaraA John Barrett

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Citations

Oct 29, 2011·Cancer Immunology, Immunotherapy : CII·Michal Smahel
Dec 18, 2012·Cancer Cell International·Yangqiu LiChristian A Schmidt
Jan 9, 2014·International Journal of Hematology·Monica BocchiaAnna Sicuranza
Feb 22, 2012·Immunotherapy·Vladimír Vonka
Mar 3, 2015·Expert Review of Clinical Immunology·Vladimír Vonka, Martina Petráčková
Jan 5, 2011·Clinical & Developmental Immunology·Zuzana HumlováVladimír Vonka
May 8, 2015·Oncoimmunology·Vladimir VonkaZdenek Roth
Mar 9, 2021·World Journal of Clinical Oncology·Mariana Miranda SampaioFabrício Freire de Melo
Jan 24, 2019·Cell Regeneration·Zhenyi JinYangqiu Li

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Methods Mentioned

BETA
in silico methods

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