Immunotherapy of experimental and human stroke with agents approved for multiple sclerosis: a systematic review

Therapeutic Advances in Neurological Disorders
Mirjam DreikornPeter Kraft

Abstract

'Thromboinflammation' describes a novel concept in stroke pathophysiology that has opened up the possibility of immunotherapeutic approaches which could become promising strategies for targeted stroke therapies in the future. We reviewed current evidence for agents approved for multiple sclerosis in preclinical and clinical stroke studies. A systematic review was performed in accordance with the PRISMA statement, searching MEDLINE, the Cochrane Central Register of Controlled Trials, and reference lists of articles published until 16 October 2017. The review included 52 of 629 identified studies, consisting of 5 clinical and 47 preclinical trials. Most of the studies showed beneficial effects of the evaluated immunotherapeutic drugs in terms of reduction in morphological lesion size and improvement in functional outcome. Nevertheless, the significance of these findings is limited due to the high degree of heterogeneity. Immunotherapy of stroke might be effective and could become a promising treatment strategy, but larger clinical trials with standardized interventions and outcome measures are needed.

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Citations

Oct 20, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gina HadleyAlastair M Buchan
Dec 20, 2018·Physiological Reviews·Meng XuHongliang Li
Dec 21, 2020·Trends in Pharmacological Sciences·Shenpeng R ZhangChristopher G Sobey
Dec 11, 2020·Circulation Research·Anja NitzscheEric Camerer
Feb 11, 2021·Journal of Clinical Medicine·Athina-Maria AloizouEfthimios Dardiotis
Oct 6, 2020·Brain, Behavior, and Immunity·Damien LevardMarina Rubio
Apr 9, 2021·The European Journal of Neuroscience·Vishal ChavdaBipin Chaurasia

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Methods Mentioned

BETA
transgenic

Clinical Trials Mentioned

NCT02730455
NCT02956200

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