Immunotherapy of head and neck tumors: Highlights of the ASCO Meeting 2015

HNO
S LabanT K Hoffmann

Abstract

In recent years, new immunotherapeutic drugs have become available: the so-called immune checkpoint modulators. With these drugs, unprecedented treatment results have been achieved in different malignant diseases; primarily malignant melanoma, but also in various other malignomas. These achievements have revolutionized the oncologic treatment landscape. This quickly expanding research field, driven by revolutionary treatment results, has put immunotherapy in the focus of attention. Due to rapid developments in the field of immunotherapy, this article aims at introducing, illustrating, and summarizing the field of modern immunotherapy, based on recently presented clinical data from the Annual Meeting of the American Society of Clinical Oncology (ASCO) 2015. The most important ASCO Meeting 2015 immunotherapy trials for head and neck squamous cell carcinoma (HNSCC) were identified, summarized, and discussed with respect to the current state of research. The oncologic landscape of clinical trials is currently dominated by the new immune checkpoint modulating drugs. Also for HNSCC, a variety of clinical trials and substances are under way. The current primary focus of these trials is targeting and inhibiting the programmed death 1 (...Continue Reading

References

Nov 15, 2005·International Journal of Cancer. Journal International Du Cancer·Thomas K HoffmannTheresa L Whiteside
Sep 12, 2008·The New England Journal of Medicine·Jan B VermorkenRicardo Hitt
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Moniek HeusinkveldSjoerd H van der Burg
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Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J B Vermorken, P Specenier
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Nov 18, 2014·The New England Journal of Medicine·Caroline RobertPaolo A Ascierto
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
Jun 2, 2015·The New England Journal of Medicine·James LarkinJedd D Wolchok

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