Immunotherapy of hepatocellular carcinoma with a vaccine based on xenogeneic homologous alpha fetoprotein in mice

Biochemical and Biophysical Research Communications
Wei ZhangYu-Quan Wei

Abstract

alpha-Fetoprotein (AFP) is a diagnostic marker for the presence of hepatocellular carcinoma, and a potential target for immunotherapy. Unfortunately, the immunity to AFP is presumably difficult to elicit because of immune tolerance acquired during the development of immune system. In the present study, we used AFP as a model antigen to explore the feasibility of the immunotherapy of AFP-positive liver cancer by the breaking of immune tolerance against AFP in a cross-reaction between the xenogeneic homologues and self molecules. Recombinant rat AFP was prepared as a vaccine, and mouse AFP was prepared as a control. Immunized with rat AFP was effective at protective and therapeutic antitumor immunity in hepatocellular carcinoma model in mice. Both humoral and cellular immune responses may be responsible for the antitumor activity against AFP-positive tumor cells, and no marked side effects were observed in the immunized mice. Thus, our study may provide an effective vaccine strategy for the treatment of AFP-positive hepatocellular carcinoma, and may be of importance to further exploration of the breaking of immune tolerance to self molecules.

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Citations

May 30, 2014·International Journal of Molecular Sciences·Thomas TuNicholas A Shackel
Jul 16, 2014·Expert Opinion on Biological Therapy·Federica CavalloGennaro Ciliberto
Feb 12, 2011·The Journal of International Medical Research·Q G LaiK F Yuan
May 23, 2018·Journal of Immunology Research·Yingjun XieXuewen Zhang
Jul 25, 2019·World Journal of Gastroenterology : WJG·Yu JiangJian Zhang
Aug 15, 2018·Journal of Clinical Medicine·Meng-Yu WuChia-Jung Li

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