PMID: 6403549Jan 1, 1983Paper

Immunotherapy of human leukemia with antibody to pluripotential K-562 stem cells

Journal of Cancer Research and Clinical Oncology
J IzquierdoW Hanna

Abstract

Gamma (gamma) globulin was fractionated from the serum of a goat immunized with the pluripotential leukemia cell line K-562. The lyophilized gamma-globulin preparation, termed leukoglobulin, contained about 50% immune IgG and suppressed the proliferation of heterotransplanted leukemia and lymphoma cells of human origin. The main aims of this study were to evaluate the potential therapeutic value of leukoglobulin and to determine its toxicity in humans with terminal leukemia and patients whose disease was unresponsive to current therapy. Two patients with CML, one with AMML, four with ALL, and one with AML were treated once a week for up to 5 weeks with leukoglobulin intravenously at doses ranging from 2 to 29 mg/kg. Leukoglobulin was well tolerated with minimal adverse effects and produced an initial mobilization of blasts from the bone marrow, spleen, and other organs with a parallel increase in the number of blasts in the systemic circulation. Subsequent injections of leukoglobulin led to a sharp decrease and the eventual eradication of blasts from the peripheral blood and bone marrow. Except in patients with CML, immature cells other than blasts also markedly diminished. The results of the clinical trials indicated a synergi...Continue Reading

References

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Citations

Jan 27, 2007·Journal of Translational Medicine·Annette M MarleauThomas E Ichim
Jun 13, 2014·Integrative Zoology·Nathan S Hart, Shaun P Collin

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