Immunotherapy of patients with recurrent spontaneous miscarriage and idiopathic infertility: does the immunization-dependent Th2 cytokine overbalance really matter?

Archivum Immunologiae Et Therapiae Experimentalis
Jacek R WilczyńskiMałgorzata Banasik

Abstract

Recurrent spontaneous miscarriage (RSM) and idiopathic infertility (IIF) are partially caused by immunologic disturbances. Paternal lymphocyte immunization (PLI) is proposed for restoration of the proper Th1/Th2 balance in these patients, but still there are controversies on PLI mechanism, its efficacy and identification of patients who may benefit from this therapy. The study group consisted of n = 34 RSM and n = 42 IIF women with unexplained miscarriage or IIF. PLI was offered as a treatment in both groups. Peripheral blood lymphocyte (PBL) populations (CD3(+), CD3(-)/CD19(+), CD3(+)/CD4(+), CD3(+)/CD8(+), CD3(-)/CD16(+)CD56(+)) were studied before immunization, while PBL cytokine secretion (IFN-γ, TNF-α, IL-10, IL-5, IL-4, IL-2), before and after immunization, pre-conceptionally in both groups. The reference PBL ratio and cytokine levels were adopted from previously studied normal fertile women. PBL populations, concentration and ratio of Th1/Th2 cytokines did not differ between RSM and IIF patients. Compared to the results observed in normal fertile women the levels of IFN-γ, TNF-α and IL-2 were higher, while IL-10 lower in both RSM and IIF patients (p < 0.01). After immunization a decrease of IFN-γ (RSM and IIF groups) and...Continue Reading

References

May 1, 1991·American Journal of Reproductive Immunology : AJRI·T SugiR Iizuka
Jul 1, 1990·Journal of Reproduction and Fertility·G ChaouatT G Wegmann
Jan 1, 1995·American Journal of Reproductive Immunology : AJRI·C B CoulamK D Beaman
Jan 1, 1994·Critical Reviews in Immunology·S A RobertsonT G Wegmann
Jun 28, 1995·JAMA : the Journal of the American Medical Association·J A HillD J Anderson
Dec 4, 1998·Springer Seminars in Immunopathology·B MüllerZ Yin
Dec 31, 1998·American Journal of Reproductive Immunology : AJRI·J Y KwakA E Beer
Oct 12, 2000·American Journal of Reproductive Immunology : AJRI·R RamhorstL Fainboim
Jul 5, 2001·Journal of Reproductive Immunology·L SvenssonR Mattsson
Jan 9, 2003·American Journal of Reproductive Immunology : AJRI·Ana C ZenclussenPetra C Arck
Dec 4, 2003·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
Apr 15, 2004·Immunology Letters·Gerard ChaouatJacques Martal
Aug 4, 2004·Journal of Reproductive Immunology·Ole B ChristiansenBjorn Pedersen
Aug 4, 2004·Journal of Reproductive Immunology·Silvia DaherRosiane Mattar
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn
Jan 26, 2005·American Journal of Reproductive Immunology : AJRI·David A Clark, Gerard Chaouat
Apr 7, 2005·Journal of Reproductive Immunology·Shigeru SaitoMasatoshi Sakai
Apr 21, 2006·The Cochrane Database of Systematic Reviews·T F PorterJ R Scott
Feb 14, 2007·American Journal of Reproductive Immunology : AJRI·Meen-Yau ThumAmolak Bansal
Jul 20, 2007·The Cochrane Database of Systematic Reviews·J R Scott, N Pattison
Feb 16, 2008·American Journal of Reproductive Immunology : AJRI·Behrouz Gharesi-FardEskandar Kamali-Sarvestani
Nov 27, 2008·The Journal of Clinical Investigation·Vicki PlaksSteffen Jung
Dec 6, 2008·American Journal of Reproductive Immunology : AJRI·Edward E WingerMohamed Taranissi
Jan 24, 2009·Biology of Reproduction·Shawn P MurphyB Anne Croy

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Citations

Oct 2, 2013·Journal of Human Reproductive Sciences·Ahad ZareMaryam Nourizadeh
Aug 5, 2015·Women's Health·Angena Agenor, Sohinee Bhattacharya
Oct 31, 2017·American Journal of Reproductive Immunology : AJRI·Fanfan LiDongrui Deng
Aug 27, 2018·Journal of the Chinese Medical Association : JCMA·Hajar Adib RadShima Soleimani Amiri
Feb 11, 2020·Journal of Human Reproductive Sciences·Motahareh EhsaniMehdi Shahbazi
Feb 28, 2021·American Journal of Reproductive Immunology : AJRI·Marcelo Borges CavalcanteRicardo Barini

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