Immunotherapy of solid cancer using dendritic cells pulsed with the HLA-A24-restricted peptide of carcinoembryonic antigen

Cancer Immunology, Immunotherapy : CII
Tsuyoshi ItohHisakazu Yamagishi

Abstract

Carcinoembryonic antigen (CEA), an oncofetal glycoprotein overexpressed in most gastrointestinal and lung cancers, is a candidate molecule for cancer immunotherapy. Recently, a CEA-derived 9-mer peptide, CEA652 (TYACFVSNL), has been identified as the epitope of cytotoxic T lymphocytes restricted with human leukocyte antigen (HLA)-A24, which is present in 60% of the Japanese population and in some Caucasians. The authors performed a clinical study of a vaccine using autologous dendritic cells (DCs) pulsed with CEA652 and adjuvant cytokines, natural human interferon alpha (nhuIFN-alpha), and natural human tumor necrosis factor alpha (nhuTNF-alpha), for the treatment of patients with CEA-expressing advanced metastatic malignancies. Ten HLA-A24 patients with advanced digestive tract or lung cancer were enrolled in the study to assess toxicity, tolerability and immune responses to the vaccine. DCs were generated from plastic adherent monocytes of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood mononuclear cells (PBMCs) in the presence of granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). Generated DCs showing an immature phenotype were loaded with CEA652 and injected into pat...Continue Reading

Citations

Jun 26, 2007·Current Oncology Reports·Carol Albright, Jennifer Garst
Feb 6, 2007·Thyroid : Official Journal of the American Thyroid Association·Koichiro KuwabaraNaohide Yamashita
Sep 29, 2011·The Cancer Journal·Ronan J Kelly, Giuseppe Giaccone
Oct 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J BarthMarc S Ernstoff
Mar 11, 2009·Journal of Biomedical Science·Pablo MatarGuillermo Mazzolini
Jan 15, 2009·Folia Histochemica Et Cytobiologica·Olga JankowskaJacek Roliński
Feb 9, 2012·International Journal of Pediatrics·Allison B DartHeather J Dean
Jan 23, 2004·Cancer Investigation·Derry Ridgway
Oct 3, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M M AloysiusO Eremin
Jul 16, 2008·Experimental Hematology·Sagar LonialEdmund K Waller
Mar 16, 2004·Cancer Science·Yuichi NakamuraMasaharu Nishimura
Feb 26, 2011·Clinical & Developmental Immunology·Zheng-Cai JiaYu-Zhang Wu
Jul 19, 2015·Biochemical and Biophysical Research Communications·Bingtan SongHui Qu
Oct 7, 2015·Current Colorectal Cancer Reports·Timothy J Zumwalt, Ajay Goel
Oct 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deirdre O'MahonyMartin E Gutierrez
Jul 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward A HirschowitzJohn Yannelli
Apr 8, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W J LesterhuisC J A Punt
Feb 12, 2014·Journal of Cancer Research and Therapeutics·Qi LuWeiping Li
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil L Berinstein
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Isabelle BedrosianBrian J Czerniecki
May 10, 2016·World Journal of Gastroenterology : WJG·Mikio KajiharaShigeo Koido
Sep 9, 2016·World Journal of Gastroenterology : WJG·Xuan SunJun Yan
Nov 8, 2002·British Medical Bulletin·Caroline L SmithVincenzo Cerundolo
Jan 17, 2020·Journal of Cellular Biochemistry·Chunjue YuanYunbao Pan
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dirk Nagorsen, Eckhard Thiel
Dec 22, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amanda L WoosterDevin B Lowe
Mar 9, 2021·Frontiers in Immunology·Dieter StevensKarim Vermaelen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.