Immunotherapy of type 1 diabetes

Archivum Immunologiae Et Therapiae Experimentalis
Li LiBo Wang

Abstract

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing beta cells are destroyed. Diabetic patients manage their hyperglycemia by daily insulin injections. However, insulin therapy is by no means a cure. Accordingly, a significant effort has been ongoing to develop immunotherapies that effectively prevent and/or treat T1D in the clinic. This review focuses on antigen- and antibody-based immunotherapies and discusses the respective strengths and weaknesses of these approaches.

Citations

Nov 3, 2011·Journal of Transplantation·Preeti Chhabra, Kenneth L Brayman
Jan 26, 2010·Expert Opinion on Biological Therapy·Umesh B Masharani, Joseph Becker

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