Apr 10, 2013

Immunotherapy targeting misfolded proteins in neurodegenerative disease

Brain and nerve = Shinkei kenkyū no shinpo
Kazutomi Kanemaru

Abstract

Aberrant protein aggregation is closely linked to the molecular pathogeneses of most neurodegenerative diseases. The major components of pathological aggregates have been characterized in various neurodegenerative diseases; for example, amyloid β-protein and phosphorylated tau in Alzheimer's disease, α-synuclein in Parkinson's disease, SOD1 or TDP-43 in amyotrophic lateral sclerosis, and huntingtin in Huntington's disease. These misfolded protein aggregates play a vital role in disease initiation and progression, and they have recently been shown to have prion-like spreading or seeded aggregation properties. Immunotherapy with specific monoclonal antibodies is a promising approach to clear misfolded protein aggregates and treat various neurodegenerative diseases; it is planned for use in clinical trials in the near future.

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Mentioned in this Paper

TARDBP gene
Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Pathogenesis
APP protein, human
Huntington's Disease Pathway
Aggregation
Degenerative Diseases, Spinal Cord
Transcription Initiation
Alzheimer's Disease

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