Immunotherapy with checkpoint inhibitors for lung cancer: novel agents, biomarkers and paradigms

Future Oncology
Inês-de-Paula MonteiroRamon Andrade de Mello

Abstract

Despite recent advances, prognosis of patients with advanced lung cancer remains dismal. Owing to a better understanding of the interactions between immune system and tumor cells, immunotherapy has emerged as a promising therapeutic strategy. After the recent approval of nivolumab and the promising results with other immune checkpoint inhibitors, combination strategies are now subject of intensive research. Notwithstanding these successes, immunotherapy still holds significant drawbacks. As the target shifts from tumor cells to the tumor microenvironment, treatment paradigms are changing and several improvements are needed for optimal use in clinical practice. Robust biomarkers for patient selection and a reliable way of evaluating treatment response are high priorities. Herein we review current data on immune checkpoint inhibitors for lung cancer treatment.

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Citations

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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT01642004
NCT02041533
NCT01454102
NCT02066636
NCT02409368
NCT02220894
NCT01905657
NCT01846416
NCT02409342
NCT02367781

Software Mentioned

irRC

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