PMID: 11920615Mar 29, 2002Paper

Immunotherapy with recombinant SFV-replicons expressing the P815A tumor antigen or IL-12 induces tumor regression

International Journal of Cancer. Journal International Du Cancer
P ColmeneroM Jondal

Abstract

Replicons based on alphaviruses are emerging as candidate vectors for vaccination and gene therapy purposes. We have reported previously that mice vaccinated with a recombinant Semliki Forest virus (a member of the alphavirus genus) carrying the gene encoding the P815A tumor antigen (rSFV/E-P1A) were protected against a lethal challenge with the P815 tumor. In this study we investigated the anti-tumor therapeutic efficacy of rSFV/E-P1A or rSFV expressing the cytokine interleukin 12 (rSFV/IL12) on Day 5-established tumors. The results show that both antigen-specific and cytokine-mediated rSFV treatments exhibited a significant effect on P815 tumor growth, by delaying tumor progression and even inducing complete tumor regressions in several mice. The therapeutic potency of these vectors was dependent on the size of the treated tumor, as treatment of mice bearing larger tumors showed lower efficacy. In addition, rSFV treatment resulted in long-term immunity as observed by the lack of tumor recurrence in the majority of tumor-regressing mice after rechallenge with the tumor. Furthermore, the anti-tumor therapeutic effect was only achieved by local intratumoral injection of rSFV, as treatment by injection in the contralateral site r...Continue Reading

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Citations

Apr 25, 2003·Journal of Virological Methods·Seema S GangolliJacek Kowalski
Aug 2, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Juan R Rodriguez-MadozCristian Smerdou
Oct 2, 2014·Expert Review of Vaccines·Karl Ljungberg, Peter Liljeström
Jun 18, 2014·Viruses·Kenneth Lundstrom
Jul 30, 2005·Expert Opinion on Biological Therapy·Delia J NelsonRobbert van der Most
Jul 26, 2003·Expert Opinion on Biological Therapy·Kenneth Lundstrom
Jan 21, 2016·Immunotherapy·Ruben Hernandez-AlcocebaCristian Smerdou
Aug 10, 2010·Virus Research·Jose I QuetglasCristian Smerdou
Nov 16, 2004·Experimental Physiology·Céline RhêmeDenis Grandgirard
Feb 2, 2006·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Annelies Riezebos-BrilmanToos Daemen
Aug 27, 2005·Expert Opinion on Biological Therapy·Michel AdaminaPaul Zajac
Jul 2, 2003·Expert Opinion on Biological Therapy·Wolfgang W Leitner, Josef Thalhamer
Jun 21, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Juan R Rodriguez-MadozCristian Smerdou
Oct 8, 2003·Technology in Cancer Research & Treatment·Kenneth Lundstrom, Teni Boulikas
Jun 1, 2009·Viruses·Kenneth Lundstrom
Feb 13, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jose I QuetglasCristian Smerdou
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chie Kudo-SaitoJames W Hodge
Mar 25, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chie Kudo-SaitoJames W Hodge
Nov 13, 2020·Frontiers in Immunology·Khue G NguyenDavid A Zaharoff

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