PMID: 8959646Nov 1, 1996Paper

Immunotoxic effect of low dose cisplatin in mice

The Journal of Toxicological Sciences
Y KouchiM Ohsawa

Abstract

The immunosuppressive effects of cisplatin at relatively low doses were investigated in CD-1 mice. Mice were injected intraperitoneally with 8, 40 and 200 micrograms/kg cisplatin for 10 days. A decrease in body and thymus weights was observed at 200 micrograms/kg. Though there were no dose-related effects on the IgM antibody response to sheep erythrocytes, a statistically significant reduction of the contact hypersensitivity response (CHR) was seen at 200 micrograms/kg. In vivo and in vitro effects of cisplatin on T- and B-lymphocyte function were assessed by proliferative response to concanavalin A and lipopolysaccharide, respectively. Cisplatin inhibited splenic T-lymphocyte function more than splenic B-lymphocyte function. These data indicate that a relatively low dose of cisplatin induce immunosuppressive effects in mice with a greater effect on T-lymphocytes than the B-lymphocytes.

Citations

May 1, 2008·Environmental Toxicology and Pharmacology·Amr A FouadWafaey Gomaa
Dec 2, 2005·Toxicology Letters·Waldemar WagnerJarosław Dastych
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Silvia C Formenti, Sandra Demaria
Apr 20, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Milos ArsenijevicVladislav Volarevic
May 28, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Abdelazeem Ali KhalafAnupam Bishayee
Mar 9, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hyo-Seon KimChang-Gue Son
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

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