PMID: 9432528Feb 12, 1998Paper

Immunotoxicity of drugs

Journal de pharmacie de Belgique
C J Charlier, G J Plomteux

Abstract

Immunotoxicity of drugs represents an important problem for 10 to 12% of the overall population. There are 4 types immunotoxicological manifestations of drugs: immediate hypersensitivity, cytotoxic reactions, immune complexes reactions and delayed-type hypersensitivity. The most frequently concerned drugs are penicillins, cephalosporins, anesthetics (type I), erythromycin estolate, nitrofurantoin, sulfonamids, antitubercular agents (type II), quinidine, ticarcillin, valproate, pyramidon (type III) and finally for type IV, topical drugs (antihistaminic products, oestradiol, s.c. heparin).

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