Immunotoxicity of nanoparticle nTiO2 to a commercial marine bivalve species, Tegillarca granosa

Fish & Shellfish Immunology
Wei ShiGuangxu Liu

Abstract

The increasing production and extensive application of nanoparticles (NPs) inevitably leads to increased release of NPs into the marine environment and therefore poses a potential threat to marine organisms, especially the sessile benthic bivalves. However, the impacts of NPs on the immunity of commercial and ecological important bivalve species, Tegillarca granosa, still remain unknown to date. In addition, the molecular mechanism of the immunotoxicity of NPs still remains unclear in marine invertebrates. Therefore, the immunotoxicity of nTiO2 exposure to T. granosa at environmental realistic concentrations was investigated in the present study. Results obtained showed that the total number, phagocytic activity, and red granulocytes ratio of the haemocytes were significantly reduced after 30 days nTiO2 exposures at the concentrations of 10 and 100 μg/L. Furthermore, the expressions of genes encoding Pattern Recognition Receptors (PPRs) and downstream immune-related molecules were significantly down-regulated by nTiO2 exposures, indicating a reduced sensitivity to pathogen challenges. In conclusion, evident immunotoxicity of nTiO2 to T. granosa at environmental realistic concentrations was detected by the present study. In addi...Continue Reading

Citations

Mar 30, 2019·Environmental Science and Pollution Research International·Vanessa Koehlé-DivoBénédicte Sohm
Aug 14, 2018·Fish & Shellfish Immunology·Jing Liu, Yong Zhao
May 15, 2021·Journal of Environmental Sciences (China)·Zhuoqing LiYouji Wang
Jun 1, 2020·Ecotoxicology and Environmental Safety·Hany M R Abdel-LatifMansour El-Matbouli

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