Immunotoxicity of the pyrethroid insecticides deltametrin and alpha-cypermetrin

Toxicology
C MadsenC Röpke

Abstract

The synthetic pyrethroids deltametrin and alpha-cypermetrin were studied for effects on the immune system in 28-day studies in F344 male rats. Sixteen rats per group were dosed with either deltametrin 0, 1, 5, or 10 mg/kg body wt./day or alpha-cypermertin 0, 4, 8, or 12 mg/kg body wt./day in soy bean oil by gavage. Haematology, bone marrow cell counts, tests for natural killer (NK) cell activity and mitogen response (Con A and STM) as well as quantitation of lymphocyte subpopulations were performed. Spleen cells from immunized animals (six animals/group) were tested for antibody production (SRBC-PFC). Volumes of lymphoid compartments of mesenteric lymph nodes and thymus were estimated using stereological methods. In the deltametrin study an effect was found in the groups receiving 5 or 10 mg/kg body wt. The effects were: increased weight of mesenterial lymph nodes, decreased thymus weight in immunized animals and an increase in numbers of SRBC-PFC and splenic NK cell activity. An effect on relative adrenal weight was seen in the 10 mg/kg body wt. group. No severe effects on the immune system was found. The lowest effect level of alpha-cypermetrin was 12 mg/kg body wt./day based on increased relative adrenal weight.

References

Dec 1, 1992·Environmental Research·J Lukowicz-Ratajczak, J Krechniak
Jan 1, 1990·Toxicologic Pathology·J K MaurerR D Bruce
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Dec 1, 1986·Ecotoxicology and Environmental Safety·I DésiL Varga
Sep 15, 1984·Toxicology and Applied Pharmacology·K M Crofton, L W Reiter
May 1, 1994·Human & Experimental Toxicology·O SirokiI Desi

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Citations

Mar 27, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K PunareewattanaS D Holladay
Nov 26, 2010·Journal of Agricultural and Food Chemistry·Ki Chang AhnBruce D Hammock
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Karen M SemchukDonald G Irvine
Mar 10, 2009·Journal of Toxicology and Environmental Health. Part a·Jennifer M W FroeseMark L Wickstrom
Apr 21, 2012·Pakistan Journal of Biological Sciences : PJBS·W A SakaT R Babatunde
Apr 1, 2015·Drug and Chemical Toxicology·Tatiana Fernandes Araujo AlmeidaEtel Rocha-Vieira
Nov 4, 2008·Autonomic Neuroscience : Basic & Clinical·Gordana LeposavićDusko Kosec
Jan 21, 2009·Journal of Applied Toxicology : JAT·Rosita GabbianelliCinzia Nasuti
Sep 21, 2010·Environmental Toxicology and Chemistry·Ying ZhangWeiping Liu
Jan 29, 2011·Scandinavian Journal of Immunology·H RehmanS Raisuddin
Nov 23, 2012·Environmental Toxicology·Yuanxiang JinZhengwei Fu
Aug 28, 2004·Toxicology Letters·Welligton L BraguiniMaria Benigna M de Oliveira
Apr 24, 2003·International Journal of Hygiene and Environmental Health·Wolfgang HadnagyHelga Idel
Dec 19, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Seul Min ChoiByung Mu Lee
Sep 24, 2009·Chemico-biological Interactions·Rosita GabbianelliMasayasu Inoue
Jul 1, 2005·Environmental Toxicology and Pharmacology·Chansak SuwanchaichindaJutamaad Satayavivad
Mar 3, 2017·Environmental Toxicology·Xia WangZhengwei Fu
Aug 18, 2009·Revista Da Sociedade Brasileira De Medicina Tropical·Cleide Maria Ribeiro de AlbuquerqueLuciana Iannuzzi
Oct 30, 2008·Journal of Immunotoxicology·O N OfordileS D Holladay
Dec 30, 2017·Journal of Exposure Science & Environmental Epidemiology·Jonathan Côté, Michèle Bouchard
Nov 13, 2008·International Immunopharmacology·D A RighiJ Palermo-Neto

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