PMID: 2113877May 1, 1990Paper

Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subchronic administration to C57Bl/6 mice

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
J A Deyo, N I Kerkvliet

Abstract

Monocrotaline (MCT) is a member of a class of compounds known as pyrrolizidine alkaloids (PAs). PAs are found in the leaves and seeds of a variety of plant species. The potential intoxication of livestock and man through the ingestion of contaminated grains and other foods makes PAs a significant toxicological concern. MCT exposure in rats results in lesions to hepatic and cardiopulmonary tissues as well as alterations in lymphoid organ cellularity. However, no previous studies have investigated MCT-induced functional alterations in the immune system. In the present study, MCT was administered by gavage for 14 days at 0, 10, 25, 50, 75, and 150 mg/kg to female C57Bl/6 mice. The antibody-mediated immune response to sheep red blood cells (SRBC) was assessed using the plaque-forming cell (PFC) assay and the hemolytic antibody isotope release assay (HAIR). Additionally, the cytotoxic T-lymphocyte (CTL) response to allogeneic P815 tumor cells was determined after MCT exposure. Although hepatic and pulmonary lesions are common sequelae to MCT exposure in rats, the C57Bl/6 mouse appeared to be more resistant to these effects on the basis of histopathological examination. Furthermore, the overt toxicity of MCT was minimal with respect ...Continue Reading

Citations

Jan 1, 1991·Toxicology·J A Deyo, N I Kerkvliet
Dec 18, 2008·BMC Pulmonary Medicine·Rio DumitrascuRalph T Schermuly
Feb 2, 2013·Pulmonary Circulation·Mita DasJames West
Jan 1, 1995·Environmental and Molecular Mutagenesis·M J HigginsS B Friedman

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