PMID: 2495254Jan 1, 1989Paper

Immunotoxicity studies of PCB (Aroclor 1254) in the adult rhesus (Macaca mulatta) monkey--preliminary report

International Journal of Immunopharmacology
H TryphonasZ Zawidzka

Abstract

The effects of PCB (Aroclor 1254) on the immune system of adult female rhesus monkeys were investigated in a chronic study wherein five groups of monkeys (16/group) were administered (orally) PCB at levels of 0.0, 5.0, 20.0, 40.0 or 80.0 micrograms/kg body wt daily. Tests for immunotoxicity were initiated at 23 months of exposure to PCB, at which time the monkeys had achieved an apparent pharmacokinetic steady state based on the PCB concentration in fat and/or blood. A statistically significant (P less than 0.05) dose response reduction in antibody levels (IgG and IgM) to sheep red blood cells (SRBC) was observed following i.v. administration of three immunizing doses of SRBC at weekly intervals. A statistically significant decrease in the percent TH and an increase in the percent and absolute TS lymphocyte levels was found in the 80 micrograms/kg body wt group compared to the control. The TH/TS ratio was also significantly lower in the 80 micrograms/kg body wt group compared to the control. Other parameters investigated including percent of B-lymphocytes and total T-lymphocytes, total serum immunoglobulin levels (IgG, IgM and IgA), other serum proteins, glucocorticosteroid levels and lymphocyte transformation results following...Continue Reading

References

Mar 1, 1979·Bulletin of Environmental Contamination and Toxicology·K KuwabaraN Kunita
Feb 1, 1986·Archives of Environmental Contamination and Toxicology·L TryphonasD L Arnold
Jan 1, 1985·International Journal of Immunopharmacology·P A TalcottJ H Exon
Jan 1, 1984·American Journal of Industrial Medicine·Y C Lü, P N Wong
Aug 1, 1983·Journal of Toxicology and Environmental Health·P A Talcott, L D Koller
Jan 1, 1980·Archives of Environmental Contamination and Toxicology·M R BleavinsR K Ringer
Sep 1, 1982·Archives of Environmental Contamination and Toxicology·J TrueloveZ Zawidzka
Apr 1, 1972·Environmental Health Perspectives·J G Vos
Jun 1, 1978·Environmental Health Perspectives·F CordleR Shapiro

❮ Previous
Next ❯

Citations

Jan 11, 1991·International Journal of Immunopharmacology·H TryphonasD L Arnold
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldK Karpinski
Nov 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldJ R Tanner
Jun 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldS Hayward
Oct 19, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F BryceD L Arnold
Apr 21, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldS Fernie
Feb 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldI Greer
May 5, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D L ArnoldS Malcolm
Oct 13, 1998·Toxicology·J G Vos, H Van Loveren
Nov 3, 2005·Journal of Toxicology and Environmental Health. Part a·Milton LevinSylvain De Guise
Jan 13, 2006·Journal of Toxicology and Environmental Health. Part a·Chiharu MoriSylvain De Guise
May 20, 2005·Journal of Toxicology and Environmental Health. Part a·Milton LevinSylvain De Guise
Dec 18, 2001·Environmental Health Perspectives·H Tryphonas
Apr 1, 1993·Environmental Health Perspectives·M I Luster, G J Rosenthal
Dec 1, 1995·Environmental Health Perspectives·K KrzystyniakM Fournier
Dec 1, 1995·Environmental Health Perspectives·H Tryphonas
Oct 2, 1998·Environmental Health Perspectives·I GerhardB Runnebaum
Aug 10, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A BourdonP A White
May 26, 2009·Regulatory Toxicology and Pharmacology : RTP·Nathalie ArnichRemi Maximilien
Dec 30, 2006·Regulatory Toxicology and Pharmacology : RTP·H G AbadinF T Llados
Feb 24, 2011·Environmental Toxicology·Bayram YilmazDavid O Carpenter
Jan 27, 1998·Regulatory Toxicology and Pharmacology : RTP·H R PohlC H Chou
Jul 19, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B AntonijevicD Tomic-Naglic
Jan 1, 1995·Critical Reviews in Toxicology·R D Kimbrough
Jan 1, 1992·Critical Reviews in Food Science and Nutrition·D M Hinton
May 4, 2007·Regulatory Toxicology and Pharmacology : RTP·Ted SimonRobert C James
Jan 1, 1995·Human & Experimental Toxicology·H Tryphonas
Oct 30, 2008·Journal of Immunotoxicology·Joseph R PiccottiRoberto E Guzman
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Todd StedefordChing-Hung Hsu
Dec 29, 2020·Journal of Toxicology and Environmental Health. Part a·Patricia A FairNatasha D White

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D L ArnoldK Karpinski
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D L ArnoldJ R Tanner
© 2022 Meta ULC. All rights reserved