PMID: 6980867Jun 1, 1982Paper

Immunotoxicology studies on lead: effects of exposure on tumor growth and cell-mediated tumor immunity after syngeneic or allogeneic stimulation

Immunopharmacology
N I Kerkvliet, L Baecher-Steppan

Abstract

Chronic exposure of C57BL/6 mice to lead acetate in the drinking water enhanced the growth of primary Moloney sarcoma virus (MSV)-induced tumors. Regression of MSV-induced tumors was not prevented by lead exposure and lead-treated animals were more resistant to late sarcoma development following primary tumor regression. The primary cell-mediated cytotoxic response in the spleen or lymph nodes of MSV-tumor bearing mice was significantly augmented by lead exposure. This augmentation appeared to reflect the increased antigenic stimulation resulting from the enhanced primary tumor growth in lead-exposed animals. Using an allogeneic tumor model, under conditions of similar antigenic stimulation, little effect of lead on T cell-mediated cytotoxicity was observed. On the other hand, macrophage phagocytic activity was significantly depressed in lead-exposed mice. Coupled with a decrease in the total number of macrophages recovered from lead-exposed mice, the results suggested significant impairment of macrophages function by lead. The influence of lead-induced macrophage dysfunction on tumor growth is discussed.

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·S H SwierengaJ R McLean
Dec 1, 1994·Environmental Geochemistry and Health·P M LutzH Bengsch
Dec 24, 1997·Biological Trace Element Research·S O Knowles, W E Donaldson
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Jul 9, 2004·Toxicology and Applied Pharmacology·Rodney R DietertMichael Piepenbrink
Aug 30, 2000·International Journal of Immunopharmacology·Y O KimJ H Kim
Dec 11, 1997·Neurotoxicology and Teratology·J J MejíaM E Jiménez-Capdeville
Jan 1, 2005·Environmental Toxicology and Pharmacology·Helena Cristina da Silva de AssisCiro Alberto de Oliveira Ribeiro
Oct 20, 1999·Methods : a Companion to Methods in Enzymology·A K Hubbard
Jan 1, 1985·Toxicologic Pathology·L D KollerJ H Exon
Jan 1, 1990·Annals of the New York Academy of Sciences·L D Koller

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