IMP-3 is a novel progression marker in malignant melanoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Jennifer G PryorHaodong Xu

Abstract

Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 expression in melanocytic neoplasms has not been investigated. Fifty-six melanocytic neoplasms from 48 subjects were immunohistochemically studied using a monoclonal antibody against L523S/IMP-3. IMP-3 expression in melanoma was significantly higher than in Spitz nevi (P<0.05), and the staining intensity in the Spitz nevi was weak. IMP-3 expression in metastatic melanoma was significantly higher than in primary cutaneous melanoma with a Breslow depth </=1 mm (P<0.01). None of the benign nevi and dysplastic nevi expressed IMP-3. Our study demonstrates that IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. In conclusion, IMP-3 appears to be involved in the progression of malignant melanoma...Continue Reading

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Citations

Oct 17, 2012·Cellular and Molecular Life Sciences : CMLS·Jessica L BellStefan Hüttelmaier
Nov 10, 2009·Endocrine Pathology·Alberto RighiRicardo V Lloyd
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark J MentrikoskiHaodong Xu
Apr 13, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Michael T SchmidtHanlin L Wang
Jul 22, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Aurelia NoskeCarsten Denkert
Dec 24, 2011·European Journal of Histochemistry : EJH·L PilloniG Faa
Mar 22, 2014·Journal of Cancer Research and Clinical Oncology·Shuai HuGuoqiang Li
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Mar 19, 2011·Blood Cells, Molecules & Diseases·Mindaugas StoskusLaimonas Griskevicius
May 21, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·M R SoaresE S Ramos
Dec 17, 2009·Human Pathology·Jennifer J Findeis-HoseyHaodong Xu
Aug 25, 2009·Human Pathology·Rebecca L KingAdam Bagg
Jun 18, 2010·The Journal of Investigative Dermatology·Bonnie E Gould Rothberg, David L Rimm
Oct 1, 2009·Journal of Cutaneous Pathology·Limin YuLinglei Ma
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Jul 30, 2014·Seminars in Cancer Biology·Marcell LedererStefan Hüttelmaier
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Oct 4, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marcela ChistéMonica Recine
Aug 2, 2018·Annals of Dermatology·Jeong-Wan SeoKi-Hoon Song
Jul 9, 2020·Cancers·Valeria PietropaoloUgo Moens
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Dec 7, 2020·The Journal of Surgical Research·Akiyuki WakitaYoshihiro Minamiya
Jul 13, 2021·Investigational New Drugs·Qiu-Ying DuDong-Sheng Pei

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