Impact and management of left ventricular function on the prognosis of Takotsubo syndrome

European Journal of Clinical Investigation
I El-BattrawyI Akin

Abstract

Early research has proposed that patients with Takotsubo syndrome (TTS) could have a higher mortality rate than the general population. Our study was conducted to determine the short- and long-term outcome of TTS patients associated with a significantly compromised left ventricular function on hospital admission. Our institutional database constituted a collective of 112 patients diagnosed with TTS between 2003 and 2015. The patients were classified into two groups based on the left ventricular ejection fraction (LVEF), with those presenting with a LVEF > 35% on admission categorized into one group (n = 65, 58%) and those presenting with LVEF ≤ 35% (n=47, 42%) categorized into another group. The endpoint was the all-cause of mortality over a mean follow-up of 1529 ± 1121 days. Preliminary results indicated that patients with an EF ≤ 35% had a significantly greater risk of developing life-threatening arrhythmias, and were much more likely to suffer from cardiogenic shock. Patients often required varying forms of mechanical respiratory support. The in-hospital mortality, 30-day mortality, 1-year mortality and ongoing long-term mortality was significantly higher in TTS patients with an EF ≤ 35%. In a multivariate Cox regression an...Continue Reading

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Citations

Jan 19, 2018·QJM : Monthly Journal of the Association of Physicians·I El-BattrawyI Akin
Feb 5, 2019·European Journal of Heart Failure·Yoshihiro J Akashi
Jan 15, 2020·European Cardiology·Chiara Di FilippoCarlo Di Mario
Jun 2, 2020·Frontiers in Pharmacology·Marvin KummerIbrahim Akin

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