Impact and prognostic implications of colon cancers stage II sub-classification through the years.

International Journal of Colorectal Disease
Laura LorenzonMario Ferri

Abstract

According to the American Joint Committee on Cancer (AJCC) 7th edition, T4 colon cancers have been sub-divided into T4a and T4b, resulting in a stage II sub-classification (T3N0, T4aN0, and T4bN0). This study was aimed: (a) to investigate the impact of the AJCC 7th edition stage II sub-classification on the overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS) of colon cancer patients who underwent surgical resection and (b) to compare the last three AJCC editions for identifying stage II patients with high-risk of progression. One hundred seventy-eight stage II colon cancers out of 682 colorectal cancer patients who underwent surgical resection were selected. T4N0 were sub-divided in accordance with the AJCC 7th edition. Mean follow-up was 41.9 months. Kaplan-Meier method was employed to estimate the survival curves. OS analysis documented a significant difference between stage-sub-groups using the 6th edition; conversely, this difference was not seen if the 7th edition was applied (p = 0.03 and 0.12, respectively). Stage II DFS analysis reported a significant difference using both the AJCC 6th and 7th editions (p = 0.03 and 0.02, respectively). A significant difference was reported on stage II...Continue Reading

References

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Jul 22, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S Gollins

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Citations

Aug 26, 2014·Annals of Surgical Oncology·Min Jung KimJae-Gahb Park
Apr 16, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M La TorreV Ziparo
Feb 24, 2015·Journal of the American College of Surgeons·Laura LorenzonMario Ferri
Jun 1, 2017·Pathology, Research and Practice·Laura LorenzonGenoveffa Balducci

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