Impact and Timing of Smoking Cessation on Reducing Risk of Rheumatoid Arthritis Among Women in the Nurses' Health Studies

Arthritis Care & Research
Xinyi LiuJeffrey A Sparks

Abstract

To investigate the impact and timing of smoking cessation on developing rheumatoid arthritis (RA) and serologic phenotypes. We investigated smoking cessation and RA risk in the Nurses' Health Study (NHS) (1976-2014) and the NHS II (1989-2015). Smoking exposures and covariates were obtained by biennial questionnaires. Self-reported RA was confirmed by medical record review for American College of Rheumatology/European League Against Rheumatism criteria. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for RA serologic phenotypes (all, seropositive, seronegative) according to smoking status, intensity, pack-years, and years since cessation. Among 230,732 women, we identified 1,528 incident cases of RA (63.4% of which were seropositive) during 6,037,151 person-years of follow-up. Compared with never smoking, current smoking increased the risk of all RA (multivariable HR 1.47, 95% CI 1.27-1.72) and seropositive RA (HR 1.67, 95% CI 1.38-2.01) but not seronegative RA (HR 1.20, 95% CI 0.93-1.55). An increasing number of smoking pack-years was associated with an increased trend for the risk of all RA (P < 0.0001) and seropositive RA (P < 0.0001). With increasing duration of smoking cessatio...Continue Reading

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Citations

Feb 23, 2020·RMD Open·Axel FinckhUNKNOWN Recherche clinique en rhumatismes inflammatoires
Feb 6, 2020·Clinical Rheumatology·Deshiré Alpizar-Rodriguez, Axel Finckh
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Nov 23, 2019·Arthritis Research & Therapy·Alessandra ZaccardelliJeffrey A Sparks
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Mar 23, 2021·Autoimmunity Reviews·Nora PetrovskáMária Filková
Apr 10, 2021·RMD Open·Marie Falahee, Karim Raza

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