Impact of β-blocker selectivity on long-term outcomes in congestive heart failure patients with chronic obstructive pulmonary disease

International Journal of Chronic Obstructive Pulmonary Disease
Yoshiaki KubotaWataru Shimizu

Abstract

Chronic obstructive pulmonary disease (COPD) is present in approximately one-third of all congestive heart failure (CHF) patients, and is a key cause of underprescription and underdosing of β-blockers, largely owing to concerns about precipitating respiratory deterioration. For these reasons, the aim of this study was to evaluate the impact of β-blockers on the long-term outcomes in CHF patients with COPD. In addition, we compared the effects of two different β-blockers, carvedilol and bisoprolol. The study was a retrospective, non-randomized, single center trial. Acute decompensated HF patients with COPD were classified according to the oral drug used at discharge into β-blocker (n=86; carvedilol [n=52] or bisoprolol [n=34]) and non-β-blocker groups (n=46). The primary endpoint was all-cause mortality between the β-blocker and non-β-blocker groups during a mean clinical follow-up of 33.9 months. The secondary endpoints were the differences in all-cause mortality and the hospitalization rates for CHF and/or COPD exacerbation between patients receiving carvedilol and bisoprolol. The mortality rate was higher in patients without β-blockers compared with those taking β-blockers (log-rank P=0.039), and univariate analyses revealed ...Continue Reading

Citations

Mar 31, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Csaba András Dézsi, Veronika Szentes
Oct 23, 2017·ESC Heart Failure·Yoshiaki KubotaUNKNOWN ASIA-HF Study investigators
Jan 13, 2018·European Journal of Heart Failure·Arantxa Barandiarán AizpuruaHans-Peter Brunner-La Rocca
Aug 11, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Salvatore CorraoFrancesco Perticone
Jul 5, 2019·The Annals of Pharmacotherapy·Tracey L Mersfelder, Dane L Shiltz
Jun 21, 2017·Respiratory Research·Sean DuffyUNKNOWN NIH COPD Clinical Research Network and the Canadian Institutes of Health Research
Oct 16, 2016·Heart·Athar Ali Tajik, Kenneth Dickstein
Sep 3, 2016·American Journal of Respiratory and Critical Care Medicine·Sara RoversiAlvar Agustí
Sep 30, 2020·Journal of Clinical Medicine·Kazuto MatsunagaTsunahiko Hirano
Apr 4, 2020·The New England Journal of Medicine·Mark T DransfieldUNKNOWN BLOCK COPD Investigators
Jan 24, 2020·The New England Journal of Medicine·Shannon W FinksTimothy H Self
Mar 5, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Michael SchivoMark V Avdalovic
Nov 21, 2020·Journal of Medicinal Chemistry·Gang XingMao-Sheng Cheng
Jun 18, 2021·Vascular Health and Risk Management·Atul Pathak, Sanaa Mrabeti
Jul 1, 2021·ESC Heart Failure·Yoshiaki KubotaUNKNOWN ASIAN-HF Executive Committee
Apr 11, 2020·Life Sciences·Xiao-Fang Li, Yi-Min Mao

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