Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus

Antimicrobial Agents and Chemotherapy
Vincent DubéeJean-Luc Mainardi

Abstract

The production of β-lactamases Bla(Mab) and BlaC contributes to β-lactam resistance in Mycobacterium abscessus and Mycobacterium tuberculosis, respectively. Ceftaroline was efficiently hydrolyzed by these enzymes. Inhibition of M. tuberculosis BlaC by clavulanate decreased the ceftaroline MIC from ≥ 256 to 16 to 64 μg/ml, but these values are clinically irrelevant. In contrast, the ceftaroline-avibactam combination should be evaluated against M. abscessus since it inhibited growth at lower and potentially achievable drug concentrations.

References

Mar 1, 1990·Journal of Bacteriology·V Jarlier, H Nikaido
Sep 1, 1983·Antimicrobial Agents and Chemotherapy·M H Cynamon, G S Palmer
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Eric SauvagePaulette Charlier
Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
Oct 6, 2007·Biochemistry·Jean-Emmanuel Hugonnet, John S Blanchard
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E Yoko FuruyaEric V Granowitz
Jan 12, 2010·Trends in Microbiology·Halima MedjahedJean-Marc Reyrat
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Joeli MarreroSabine Ehrt
Sep 14, 2010·American Journal of Respiratory and Critical Care Medicine·Won-Jung KohO Jung Kwon
Nov 26, 2010·Journal of Clinical Microbiology·Edouard MacherasBeate Heym
Feb 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julie JarandCharles L Daley
Feb 1, 2012·The Journal of Antimicrobial Chemotherapy·Rachid NessarBrigitte Gicquel
Sep 21, 2013·Current Opinion in Pulmonary Medicine·Janice M Leung, Kenneth N Olivier
Oct 12, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M LavollayJ-L Mainardi
Oct 18, 2013·The Journal of Antimicrobial Chemotherapy·Daria SorokaMichel Arthur
Nov 26, 2013·Lancet·Alimuddin Zumla Baroness Masham of Ilton
Aug 3, 2014·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Anne-Laure RouxUNKNOWN OMA group
Dec 20, 2014·The Journal of Antimicrobial Chemotherapy·Vincent DubéeMichel Arthur

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Citations

Mar 2, 2016·The Journal of Antimicrobial Chemotherapy·Anne-Laure LefebvreJean-Luc Mainardi
Jun 5, 2016·Asian Pacific Journal of Tropical Medicine·Ryong KongDong-Yeul Kwon
Jul 19, 2016·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ana RamírezPablo Power
Oct 4, 2016·Expert Review of Anti-infective Therapy·Faiza MougariEmmanuelle Cambau
Oct 25, 2017·Antimicrobial Agents and Chemotherapy·Michael Dal MolinPeter Sander
Feb 13, 2019·Antimicrobial Agents and Chemotherapy·Elizabeth Story-RollerGyanu Lamichhane
Jan 18, 2020·Antibiotics·Clara M BentoTânia Silva
Dec 3, 2016·Open Biology·Anne-Laure RouxJean-Louis Herrmann
Jul 8, 2015·Antimicrobial Agents and Chemotherapy·Daria SorokaMichel Arthur
Apr 8, 2020·Antimicrobial Agents and Chemotherapy·Vincent Le MoigneJean-Louis Herrmann
Jun 6, 2018·Frontiers in Microbiology·Dinah B AzizThomas Dick
Oct 16, 2018·Frontiers in Microbiology·Elizabeth Story-RollerGyanu Lamichhane
Sep 30, 2017·The Journal of Antimicrobial Chemotherapy·Anna RominskiPeter Sander
Jun 23, 2020·ACS Pharmacology & Translational Science·Bikash Baral, M R Mozafari
Jun 12, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David C NguyenRobert A Bonomo

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