PMID: 25788255Mar 20, 2015Paper

Impact of 10- and 13-valent pneumococcal conjugate vaccines on incidence of invasive pneumococcal disease in children aged under 16 years in Germany, 2009 to 2012

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
Susanne WeißRüdiger von Kries

Abstract

We assessed the impact of 10-valent and 13-valent pneumococcal vaccines (PCV10 and PCV13), which were introduced in Germany in 2009, on the incidence of meningitis and non-meningitis invasive pneumococcal disease (IPD) in children aged under 16 years in a population previously vaccinated with a seven-valent vaccine (PCV7). Surveillance of IPD (isolation of Streptococcus pneumonia from a normally sterile body site) is based on data from two independent reporting sources: hospitals and laboratories. IPD incidence was estimated by capture-recapture analysis. Incidence rate ratios (IRRs) were calculated for 2009 and 2012, thus comparing pre- and post-PCV10 and PCV13 data. IPD incidence caused by serotypes included in PCV13 decreased in all age and diagnosis groups. A rise in non-vaccine serotype incidence was seen only in children aged under two years. The overall impact varied by age group and infection site: for meningitis IPD in children aged under 2, 2-4 and 5-15 years, incidence changed by 3% (95% CI: -31 to 52), -60% (95% CI: -81 to -17) and -9% (95% CI: -46 to 53), respectively. A more pronounced incidence reduction was observed for non-meningitis IPD: -30% (95% CI: -46 to -7), -39% (95% CI: -54 to -20) and -83% (95% CI: -89...Continue Reading

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Citations

Oct 16, 2015·BMC Infectious Diseases·Myint Tin Tin HtarHeinz-Josef Schmitt
Sep 21, 2016·MMW Fortschritte der Medizin·Christine VlcekAnnette Jansson
Nov 28, 2017·Current Opinion in Infectious Diseases·Matthijs C Brouwer, Diederik van de Beek
Nov 2, 2015·The European Respiratory Journal·Mathias W Pletz, Tobias Welte
Aug 2, 2019·PloS One·Mark van der LindenStephanie Perniciaro
Aug 3, 2019·Brain : a Journal of Neurology·Diederik L H KoelmanDiederik van de Beek
Nov 5, 2019·Expert Review of Vaccines·Myint Tin Tin HtarDavid Swerdlow
May 18, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Diederik L H KoelmanDiederik van de Beek
Jul 15, 2016·Deutsches Ärzteblatt International·Jörg Bätzing-FeigenbaumWinfried V Kern

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