Abstract
Recently, the authors reported an elevated prevalence of impaired glucose tolerance in individuals with multiple sclerosis (MS), compared with matched healthy controls, indicating metabolic defects that may increase comorbidity. MS also leads to a more inactive lifestyle, increasing the likelihood to develop fat accumulation, muscle wasting/weakness, and exercise intolerance. In other populations, these health complications can partly be reversed by physical exercise. The aim of this study was to determine the impact of a mild-to-moderate-intensity exercise program on glucose tolerance, ranging between normal and impaired, in persons with MS. Persons with MS (mean expanded disability status scale, 3.3 ± 0.2; mean age, 48 ± 15 yrs) were randomized to an exercise group (n = 29) or a nonexercise control group (n = 15). Glucose tolerance, as well as muscle strength, exercise tolerance, and body composition to validate the applied exercise program, was determined in both groups at baseline and after 6, 12, and 24 wks of mild-to-moderate-intensity combined endurance and resistance training. No effects on blood glucose and serum insulin were detected. However, 6 mos of exercise improved muscle strength, exercise tolerance, and lean ti...Continue Reading
References
Nov 1, 1983·Neurology·J F Kurtzke
Apr 1, 1996·Annals of Neurology·J H PetajanR W Hicks
Aug 1, 1997·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·A K Stuifbergen
Apr 17, 2002·Lancet·Alastair Compston, Alasdair Coles
Jun 6, 2002·Medicine and Science in Sports and Exercise·Jennifer N SlawtaGail Anderson
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Sep 16, 2003·Journal of Applied Physiology·Joseph A HoumardWilliam E Kraus
Sep 3, 2004·Diabetes/metabolism Research and Reviews·John A Hawley
Dec 3, 2004·Clinical Rehabilitation·Jukka SurakkaKari Mäentaka
Dec 4, 2004·Sports Medicine·Lesley J White, Rudolph H Dressendorfer
Dec 15, 2004·Neurology·A RombergA Seppänen
Nov 22, 2005·Diabetes Research and Clinical Practice·John C OldroydK G M M Alberti
Nov 25, 2005·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·John L Petersen, Darren K McGuire
Jun 17, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·L J WhiteR H Dressendorfer
Jul 4, 2006·Archives of Physical Medicine and Rehabilitation·Alexa K StuifbergenHeather A Becker
Apr 7, 2007·Diabetologia·T YatesM J Davies
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·R W Motl, J L Gosney
Sep 21, 2007·Multiple Sclerosis : Clinical and Laboratory Research·U DalgasT Ingemann-Hansen
Dec 20, 2007·Multiple Sclerosis : Clinical and Laboratory Research·R W MotlE J Stover
Jul 9, 2008·Circulation·Arnt Erik TjønnaUlrik Wisløff
Dec 15, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Tom BroekmansBert O Eijnde
Feb 16, 2012·Journal of Neurologic Physical Therapy : JNPT·Robert W MotlJacob J Sosnoff
May 1, 2012·Archives of Physiology and Biochemistry·Marit SandveiJørgen Jensen
Jul 5, 2012·Multiple Sclerosis : Clinical and Laboratory Research·T KjølhedeU Dalgas
Jul 13, 2012·Neurorehabilitation and Neural Repair·Dominique HansenBert O Eijnde
Dec 19, 2012·CNS & Neurological Disorders Drug Targets·Zohara SternbergElad Levy
Sep 3, 2013·European Heart Journal·UNKNOWN Authors/Task Force MembersRobert G Xuereb
Sep 21, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Inez WensBert O Eijnde
Citations
Jul 18, 2015·International Journal of Molecular Sciences·Arno KerlingAnja Windhagen
Mar 19, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I WensB O Eijnde
Aug 1, 2015·Current Neurology and Neuroscience Reports·Robert W Motl, Brian M Sandroff
Feb 24, 2017·Scientific Reports·Winde JorissenJerome J A Hendriks
Jul 1, 2016·American Journal of Physical Medicine & Rehabilitation·Inez WensBert O Eijnde
Jan 31, 2017·American Journal of Physical Medicine & Rehabilitation·Inez Wens, Dominique Hansen
Jan 11, 2018·International Journal of Molecular Sciences·Winde JorissenJerome J A Hendriks
Oct 28, 2017·Disability and Rehabilitation·Charly KeytsmanBert O Eijnde
Aug 14, 2019·NeuroRehabilitation·Charly KeytsmanBert O Eijnde
Sep 15, 2021·Neurology and Therapy·Marit L SchlagheckPhilipp Zimmer