Impact of 24 Weeks of Resistance and Endurance Exercise on Glucose Tolerance in Persons with Multiple Sclerosis

American Journal of Physical Medicine & Rehabilitation
Inez WensBert O Eijnde

Abstract

Recently, the authors reported an elevated prevalence of impaired glucose tolerance in individuals with multiple sclerosis (MS), compared with matched healthy controls, indicating metabolic defects that may increase comorbidity. MS also leads to a more inactive lifestyle, increasing the likelihood to develop fat accumulation, muscle wasting/weakness, and exercise intolerance. In other populations, these health complications can partly be reversed by physical exercise. The aim of this study was to determine the impact of a mild-to-moderate-intensity exercise program on glucose tolerance, ranging between normal and impaired, in persons with MS. Persons with MS (mean expanded disability status scale, 3.3 ± 0.2; mean age, 48 ± 15 yrs) were randomized to an exercise group (n = 29) or a nonexercise control group (n = 15). Glucose tolerance, as well as muscle strength, exercise tolerance, and body composition to validate the applied exercise program, was determined in both groups at baseline and after 6, 12, and 24 wks of mild-to-moderate-intensity combined endurance and resistance training. No effects on blood glucose and serum insulin were detected. However, 6 mos of exercise improved muscle strength, exercise tolerance, and lean ti...Continue Reading

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Citations

Jul 18, 2015·International Journal of Molecular Sciences·Arno KerlingAnja Windhagen
Mar 19, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I WensB O Eijnde
Aug 1, 2015·Current Neurology and Neuroscience Reports·Robert W Motl, Brian M Sandroff
Jan 11, 2018·International Journal of Molecular Sciences·Winde JorissenJerome J A Hendriks
Aug 14, 2019·NeuroRehabilitation·Charly KeytsmanBert O Eijnde

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