Impact of a 3-Months Vegetarian Diet on the Gut Microbiota and Immune Repertoire

Frontiers in Immunology
Chenchen ZhangQiang Pan-Hammarström

Abstract

The dietary pattern can influence the immune system directly, but may also modulate it indirectly by regulating the gut microbiota. Here, we investigated the effect of a 3-months lacto-ovo-vegetarian diet on the diversity of gut microbiota and the immune system in healthy omnivorous volunteers, using high-throughput sequencing technologies. The short-term vegetarian diet did not have any major effect on the diversity of the immune system and the overall composition of the metagenome. The prevalence of bacterial genera/species with known beneficial effects on the intestine, including butyrate-producers and probiotic species and the balance of autoimmune-related variable genes/families were, however, altered in the short-term vegetarians. A number of bacterial species that are associated with the expression level of IgA, a key immunoglobulin class that protects the gastrointestinal mucosal system, were also identified. Furthermore, a lower diversity of T-cell repertoire and expression level of IgE, as well as a reduced abundance of inflammation-related genes in the gut microbiota were potentially associated with a control group with long-term vegetarians. Thus, the composition and duration of the diet may have an impact on the ba...Continue Reading

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Citations

Aug 15, 2019·Experimental and Therapeutic Medicine·Qun LiuShiying Xuan
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Datasets Mentioned

BETA
ERP108062

Methods Mentioned

BETA
PCR
PCA

Software Mentioned

vegan
Permanova
R
ade4
R package

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