Oct 7, 2015

Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs

ELife
Eva MalatinkovaLinos Vandekerckhove

Abstract

Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation. We compared HIV-1 reservoirs in a cross-sectional study using polymerase chain reaction-based techniques in blood and tissue of early-treated seroconverters, late-treated patients, ART-naïve seroconverters, and long-term non-progressors (LTNPs) who have spontaneous virological control without treatment. A decade of early ART reduced the total and integrated HIV-1 DNA levels compared with later treatment initiation, but not reaching the low levels found in LTNPs. Total HIV-1 DNA in rectal biopsies did not differ between cohorts. Importantly, lower viral transcription (HIV-1 unspliced RNA) and enhanced immune preservation (CD4/CD8), reminiscent of LTNPs, were found in early compared to late-treated patients. This suggests that early treatment is associated with some immunovirological features of LTNPs that may improve the outcome of future interventions aimed at a functional cure.

  • References54
  • Citations6

References

  • References54
  • Citations6

Citations

Mentioned in this Paper

Prevalence Studies
Real-Time Polymerase Chain Reaction
Transition Zone of Anal Mucous Membrane
Amidophosphoribosyltransferase
T-Lymphocyte
Deoxyribonuclease I
Entire Rectum
Human immunodeficiency virus 1 RNA
Collection of Blood Specimen for Laboratory Procedure
Immune System Diseases

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