Impact of a deep learning assistant on the histopathologic classification of liver cancer.

NPJ Digital Medicine
Amirhossein KianiJeanne Shen

Abstract

Artificial intelligence (AI) algorithms continue to rival human performance on a variety of clinical tasks, while their actual impact on human diagnosticians, when incorporated into clinical workflows, remains relatively unexplored. In this study, we developed a deep learning-based assistant to help pathologists differentiate between two subtypes of primary liver cancer, hepatocellular carcinoma and cholangiocarcinoma, on hematoxylin and eosin-stained whole-slide images (WSI), and evaluated its effect on the diagnostic performance of 11 pathologists with varying levels of expertise. Our model achieved accuracies of 0.885 on a validation set of 26 WSI, and 0.842 on an independent test set of 80 WSI. Although use of the assistant did not change the mean accuracy of the 11 pathologists (p = 0.184, OR = 1.281), it significantly improved the accuracy (p = 0.045, OR = 1.499) of a subset of nine pathologists who fell within well-defined experience levels (GI subspecialists, non-GI subspecialists, and trainees). In the assisted state, model accuracy significantly impacted the diagnostic decisions of all 11 pathologists. As expected, when the model's prediction was correct, assistance significantly improved accuracy (p = 0.000, OR = 4.2...Continue Reading

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Citations

Jun 26, 2020·Journal of the American Medical Informatics Association : JAMIA·Melissa D McCraddenRandi Zlotnik Shaul
Aug 3, 2020·Current Opinion in Ophthalmology·J Jill HopkinsKonstantinos Balaskas
Aug 25, 2020·Journal of Magnetic Resonance Imaging : JMRI·Akshay S ChaudhariCurtis P Langlotz
Sep 11, 2020·Nature Medicine·Samantha Cruz RiveraUNKNOWN SPIRIT-AI and CONSORT-AI Consensus Group
Sep 11, 2020·BMJ : British Medical Journal·Samantha Cruz RiveraUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Sep 11, 2020·Nature Medicine·Xiaoxuan LiuUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Sep 11, 2020·BMJ : British Medical Journal·Xiaoxuan LiuUNKNOWN SPIRIT-AI and CONSORT-AI Working Group
Sep 13, 2020·BMC Medical Informatics and Decision Making·Federico CabitzaLuca Maria Sconfienza
Oct 23, 2020·World Journal of Gastroenterology : WJG·Miguel Jiménez Pérez, Rocío González Grande
Nov 19, 2020·British Journal of Cancer·Amelie EchleJakob Nikolas Kather
Feb 12, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Byoung Dai Lee, Mu Sook Lee
Feb 21, 2021·NPJ Digital Medicine·Susanne GaubeMarzyeh Ghassemi
Mar 23, 2021··Andrew Y. NgAnuj Pareek

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Methods Mentioned

BETA
surgical resection

Software Mentioned

- viewing
Windows
lme4
ObjectiveView
R
Stanford Indep
WSI

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