Impact of a Demyelination-Inducing Central Nervous System Virus on Expression of Demyelination Genes in Type 2 Lymphoid Cells.

Journal of Virology
Satoshi HiroseHomayon Ghiasi

Abstract

We recently reported the role of type 2 innate lymphoid cells (ILC2s) in central nervous system (CNS) demyelination using a model of CNS demyelination involving recombinant herpes simplex virus 1 (HSV-1) that constitutively expresses mouse interleukin 2 (HSV-IL-2). In this investigation, we studied how ILC2s respond to HSV-IL-2 at the cellular level using cytokine and gene expression profiling. ILC2s infected with HSV-IL-2 expressed higher levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-5, IL-6, IL-13, IP-10, MIP-2, and RANTES, which include proinflammatory cytokines, than did those infected with parental control virus. In contrast, TH2 cytokines IL-4 and IL-9, which are typically expressed by ILC2s, were not induced upon HSV-IL-2 infection. Transcriptome sequencing (RNA-seq) analysis of HSV-IL-2 infected ILC2s showed significant upregulation of over 350 genes and downregulation of 157 genes compared with parental virus-infected ILC2s. Gene Ontology (GO) term analysis indicated that genes related to "mitosis" and "inflammatory response" were among the upregulated genes, suggesting that HSV-IL-2 infection drives the excessive proliferation and atypical inflammatory response of ILC2s. This change in ILC2 a...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·R MartinD E McFarlin
Jan 1, 1990·Annual Review of Immunology·S S Zamvil, L Steinman
Oct 13, 1988·The New England Journal of Medicine·S J GreenbergD L Nelson
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·P B ChallonerM Chang
Dec 1, 1993·Journal of the Neurological Sciences·C Z LuH Link
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·B Roizman
Aug 1, 1997·Mayo Clinic Proceedings·S F HunterJ H Noseworthy
Sep 28, 2000·The New England Journal of Medicine·J H NoseworthyB G Weinshenker
Jun 5, 2002·Current Opinion in Neurology·Bernhard HemmerNorbert Sommer
Apr 7, 2004·The Journal of Clinical Investigation·David A Hafler
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Jan 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Deborah J LenschowHerbert Whiting Virgin
Feb 24, 2009·Investigative Ophthalmology & Visual Science·Mandana ZandianHomayon Ghiasi
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Dec 15, 2012·Nature Reviews. Immunology·Michael S Diamond, Michael Farzan
Jan 26, 2013·Nature Reviews. Immunology·Hergen SpitsEric Vivier
Oct 1, 2013·Nature Immunology·Andrew L DoedensAnanda W Goldrath
Dec 11, 2013·The Journal of Experimental Medicine·Maryam SalimiGraham S Ogg
Dec 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Emily HamsPadraic G Fallon
Jul 19, 2014·Nature Reviews. Immunology·Veit HornungKarl-Peter Hopfner
Sep 23, 2014·Immunity·Andrew N J McKenzieGerard Eberl
Jan 13, 2015·Cold Spring Harbor Perspectives in Biology·Brian S Kim, David Artis

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