Impact of a History of Hypertension in Pregnancy on Later Diagnosis of Atrial Fibrillation

Journal of the American Heart Association
Dawn C ScantleburyVesna D Garovic

Abstract

Atrial fibrillation/flutter (AF) produces significant morbidity in women and is typically attributed to cardiac remodeling from multiple causes, particularly hypertension. Hypertensive pregnancy disorders (HPDs) are associated with future hypertension and adverse cardiac remodeling. We evaluated whether women with AF were more likely to have experienced a HPD compared with those without. A nested case-control study was conducted within a cohort of 7566 women who had a live or stillbirth delivery in Olmsted County, Minnesota between 1976 and 1982. AF cases were matched (1:1) to controls based on date of birth, age at first pregnancy, and parity. AF and pregnancy history were confirmed by chart review. We identified 105 AF cases: mean age 57±8 (mean±SD) years, (controls 56±8 years), 32±8 years (controls 31±8 years) after the first pregnancy. Cases were more likely to have obesity during childbearing years, and hypertension, diabetes mellitus, dyslipidemia, coronary disease, valvular disease, and heart failure at the time of AF diagnosis. Cases were more likely to have a history of HPDs, compared with controls: 28/105 (26.7%) cases versus 12/105 (11.4%) controls, odds ratio: 2.60 (95% confidence interval, 1.21-6.04). After adjustm...Continue Reading

References

Jul 31, 2004·American Journal of Obstetrics and Gynecology·Stacie E GellerSarah J Kilpatrick
Jul 16, 2005·American Journal of Obstetrics and Gynecology·Mona T Lydon-RochelleWilliam M Callaghan
Nov 3, 2007·BMJ : British Medical Journal·Leanne BellamyDavid J Williams
Apr 26, 2008·American Journal of Hypertension·Anne B WallisHani K Atrash
Jan 21, 2010·Journal of Hypertension·Vesna D GarovicStephen T Turner
Nov 19, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·I StroblM Scheier
Nov 26, 2010·Hypertension·Karen MelchiorreBasky Thilaganathan
Mar 25, 2011·American Journal of Epidemiology·Jennifer L St SauverWalter A Rocca
Feb 13, 2013·Circulation·Tuija MännistöEila Suvanto
Dec 19, 2013·Circulation·Sumeet S ChughChristopher J L Murray
Aug 6, 2015·Heart·Dawn C ScantleburyVesna D Garovic
Mar 1, 2016·The American Journal of Cardiology·Emily Y Cheng, Melissa H Kong
Oct 7, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrea G KattahVesna D Garovic

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Citations

May 15, 2018·Journal of the American Heart Association·Renata Cífková
Feb 5, 2019·Hypertension·Basky Thilaganathan, Erkan Kalafat
May 29, 2019·Expert Opinion on Pharmacotherapy·Georgios GeorgiopoulosChristodoulos Stefanadis
Oct 30, 2018·Journal of the American Heart Association·Wendy YingPamela Ouyang
Mar 3, 2020·Frontiers in Cardiovascular Medicine·Maryam Kavousi
Dec 6, 2018·Current Cardiology Reviews·Stacy Westerman, Nanette Wenger
Mar 9, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ekrem AksuGulizar Sokmen

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