Impact of a ketogenic diet intervention during radiotherapy on body composition: II. Protocol of a randomised phase I study (KETOCOMP)

Clinical Nutrition ESPEN
Rainer J Klement, Reinhart A Sweeney

Abstract

We have found that a ketogenic diet (KD) during the course of radiotherapy (RT) was feasible and led to a preservation or favorable changes of body composition. Based on these observations and theoretical considerations, we initiated a study to investigate the impact of a KD or a ketogenic breakfast intervention in patients undergoing RT. All patients presenting for curative RT with age between 18 and 75, body mass index between 18 and 34 kg/m2 and a histologically confirmed cancer of the breast, colorectum or head and neck region are considered for inclusion. Exclusion criteria are Karnofsky index <70, pregnancy, metallic body parts that interfere with bioimpedance analysis (BIA), type I diabetes, known enzyme defects that contradict a KD and renal insufficiency. Randomization is achieved by all consecutive patients first entering the control group and then an intervention group 1 until both groups contain 15 breast, 15 colorectal and 5 head and neck cancer patients. Intervention group 1 will receive each radiotherapy fraction after an overnight fast and subsequently ingest a ketogenic breakfast consisting of (i) 50-250 ml of a medium-chain triglyceride drink (betaquick®, vitaflo, Bad Homburg, Germany) plus (ii) 5-15 g amino a...Continue Reading

Citations

Jan 24, 2018·The Cochrane Database of Systematic Reviews·Theresa A LawrieH Jervoise N Andreyev
Jan 14, 2020·Medical Oncology·Rainer J KlementReinhart A Sweeney
Mar 22, 2019·Current Nutrition Reports·Christian A Maino VieytesAnna E Arthur
May 30, 2019·Journal of Clinical Biochemistry and Nutrition·Eiji Kasumi, Norifumi Sato
Nov 25, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rainer Johannes KlementReinhart A Sweeney
May 23, 2020·Nutrients·Keisuke HagiharaTakashi Kijima
Sep 17, 2020·Gynecologic Oncology·Mariam M AlHilli, Victoria Bae-Jump
Feb 9, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rainer J KlementReinhart A Sweeney
Jul 25, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Adeleh KhodabakhshiSayed Hossein Davoodi
Apr 14, 2021·ACS Infectious Diseases·Fulvio BorellaChiara Benedetto
May 4, 2021·Critical Reviews in Food Science and Nutrition·Giovanna MuscogiuriAntongiulio Faggiano
Jul 8, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rainer J KlementReinhart A Sweeney
Dec 15, 2020·Complementary Medicine Research·Rainer Johannes KlementReinhart A Sweeney

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