Impact of a malaria intervention package in schools on Plasmodium infection, anaemia and cognitive function in schoolchildren in Mali: a pragmatic cluster-randomised trial

BMJ Global Health
Sian E ClarkeMoussa Sacko

Abstract

School-aged children are rarely targeted by malaria control programmes, yet the prevalence of Plasmodium infection in primary school children often exceeds that seen in younger children and could affect haemoglobin concentration and school performance. A cluster-randomised trial was carried out in 80 primary schools in southern Mali to evaluate the impact of a school-based malaria intervention package. Intervention schools received two interventions sequentially: (1) teacher-led participatory malaria prevention education, combined with distribution of long-lasting insecticidal nets (LLINs), followed 7 months later at the end of the transmission season by (2) mass delivery of artesunate and sulfadoxine-pyrimethamine administered by teachers, termed intermittent parasite clearance in schools (IPCs). Control schools received LLINs as part of the national universal net distribution programme. The impact of the interventions on malaria and anaemia was evaluated over 20 months using cross-sectional surveys in a random subset of 38 schools(all classes), with a range of cognitive measures (sustained attention, visual search, numeracy, vocabulary and writing) assessed in a longitudinal cohort of children aged 9-12 years in all 80 school...Continue Reading

References

May 26, 1999·International Journal of Epidemiology·R J Hayes, S Bennett
Jan 11, 2003·Advances in Parasitology·Robert W Snow, Kevin Marsh
Aug 25, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Deepika FernandoRajitha Wickremasinghe
Dec 17, 2005·American Journal of Epidemiology·A GemperliT Smith
Nov 25, 2006·The Lancet Infectious Diseases·David G LallooPiero Olliaro
Jun 6, 2009·Tropical Medicine & International Health : TM & IH·Breanna BargerAbdoulaye A Djimde
Jan 5, 2010·Malaria Journal·Rachel L PullanSimon Brooker
Apr 24, 2010·Social Science & Medicine·Josselin ThuilliezOgobara K Doumbo
Apr 17, 2013·The American Journal of Tropical Medicine and Hygiene·Joaniter NankabirwaSimon J Brooker
Jun 12, 2013·Expert Review of Anti-infective Therapy·Kim A LindbladeLaurence Slutsker
Apr 1, 2010·American Economic Journal. Applied Economics·Adrienne M Lucas
Mar 14, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joaniter I NankabirwaMoses R Kamya
Aug 26, 2014·Tropical Medicine & International Health : TM & IH·Joaniter NankabirwaBrian Greenwood
Jul 25, 2015·PloS One·Jenny A WalldorfMiriam K Laufer

❮ Previous
Next ❯

Citations

Nov 17, 2017·The American Journal of Tropical Medicine and Hygiene·Lauren M CoheeMiriam K Laufer
Nov 24, 2020·The Lancet Global Health·Anna Maria van Eijk, Jenny Hill
Mar 27, 2021·Scientific Reports·Lauren M CoheeMiriam K Laufer
Mar 27, 2021·Environmental Research·Jailos LubindaAdrian J Moore
Sep 13, 2020·Trends in Parasitology·Robert S McCannMiriam K Laufer
Apr 6, 2021·Frontiers in Immunology·Carlos Lamsfus CalleBenjamin Mordmüller

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Clinical Trials Mentioned

ISRCTN26838440

Software Mentioned

Excel
WHO AnthroPlus
TEA
Stata

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.