Impact of a Multidomain Intensive Lifestyle Intervention on Complaints About Memory, Problem-Solving, and Decision-Making Abilities: The Action for Health in Diabetes Randomized Controlled Clinical Trial

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Mark A EspelandAction for Health in Diabetes (Look AHEAD) Research Group

Abstract

Lifestyle interventions to reduce weight and increase activity may preserve higher-order cognitive abilities in overweight/obese adults with type 2 diabetes (T2D). Adults (N = 5,084) with T2D who enrolled in a randomized clinical trial of a 10-year intensive lifestyle intervention (ILI) compared with diabetes support and education were queried at baseline and repeatedly during follow-up for complaints about difficulties in memory, problem-solving, and decision-making abilities. For those without baseline complaints, assignment to ILI was associated with lower odds that complaints would emerge during follow-up for decision-making ability (odds ratio [OR]=0.851, [95% CI, 0.748,0.967], p=0.014), and, among individuals who were not obese, lower odds that complaints would emerge about problem-solving ability (OR=0.694 [0.510,0.946]). No cognitive benefits from ILI were seen for individuals with baseline complaints about cognitive abilities. ILI may have exacerbated the severity of complaints about problem-solving ability during follow-up among individuals with baseline complaints and cardiovascular disease (OR=2.949 [1.378,6.311]). A long-term multidomain ILI may reduce the likelihood that complaints about difficulties in higher-ord...Continue Reading

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Citations

Sep 29, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Felicia R SimpsonUNKNOWN Indices for Accelerated Aging in Obesity and Diabetes Ancillary Study of the Action for Health in Diabetes (Look AHEAD) Tria
Mar 23, 2021·Journal of Diabetes and Its Complications·Felicia R SimpsonUNKNOWN Indices for Accelerated Aging in Obesity and Diabetes Ancillary Study of the Action for Health in Diabetes (Look AHEAD) Tria
Nov 9, 2021·The Cochrane Database of Systematic Reviews·Melanie HafdiEdo Richard

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