Impact of a pentavalent combination vaccine on immunization timeliness in a state Medicaid population

The Pediatric Infectious Disease Journal
Laura E HappeGary S Marshall

Abstract

Use of combination vaccines has been associated with improved coverage rates, but their effect on timeliness remains to be explored. This study assessed the effect of diphtheria-tetanus-acellular pertussis/hepatitis B/inactivated polio vaccine (DTaP/HepB/IPV) on the timeliness of vaccine administration. This retrospective cohort study used administrative claims data from the Georgia Medicaid program. Children with 24 months of continuous enrollment and at least 4 vaccine-related office visits were stratified into 2 cohorts: those with at least 3 DTaP/HepB/IPV doses (DTaP/HepB/IPV cohort) and those with at least 3 doses of DTaP but no doses of DTaP/HepB/IPV (reference cohort). Children who received any dose of HepB/Hib were excluded to isolate the effect of the study vaccine. Timeliness was measured as the percentage of children who received their vaccines on time and the cumulative days undervaccinated. There were 2880 children in the DTaP/HepB/IPV cohort and 2672 in the reference cohort. After controlling for covariates, receipt of DTaP/HepB/IPV was associated with significantly improved timeliness for 3 doses of DTaP (on-time rates: 66.3% vs. 60.8%, P < 0.0001; cumulative days undervaccinated: 29.5 vs. 70.4 days, P < 0.0001)....Continue Reading

Citations

Feb 24, 2016·Journal of Immunology Research·Adi Essam ZareiElrashdy M Redwan
Jun 16, 2015·Human Vaccines & Immunotherapeutics·Khaled MamanVanessa Remy
Dec 21, 2016·Expert Review of Vaccines·Andrew W LeeGary S Marshall
Jan 21, 2017·The Pediatric Infectious Disease Journal·Samantha K KuroskyClaudia M Galindo
Jul 20, 2018·Human Vaccines & Immunotherapeutics·Girishanthy KrishnarajahPhilip O Buck
Aug 12, 2014·Expert Review of Gastroenterology & Hepatology·Viktor V ChirikovCharles D Howell
Nov 16, 2016·The Pediatric Infectious Disease Journal·Stanley L BlockAndrew W Lee
Nov 7, 2019·Human Vaccines & Immunotherapeutics·Timo VesikariAndrew Wen-Tseng Lee
Jan 24, 2021·Vaccine·Matthew M LoiaconoRobertus van Aalst

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