PMID: 16509027Mar 3, 2006Paper

Impact of a piperacillin-tazobactam shortage on antimicrobial prescribing and the rate of vancomycin-resistant enterococci and Clostridium difficile infections

Pharmacotherapy
Marisa N MendezB Joseph Guglielmo

Abstract

States in 2002 on antimicrobial prescribing and associated rates of vancomycin-resistant enterococci (VRE) and Clostridium difficile infections.Design. Retrospective chart review.Setting. University-affiliated medical center. Measurements and Main Results. Microbiologic reports, patient demographics, and antimicrobial utilization were evaluated for patients admitted 6 months before the shortage (March 1-August 31, 2001) and for 6 months during the shortage (March 1-August 31, 2002). Significant increases in usage of alternative mu-lactamase inhibitor combinations, cefepime, levofloxacin, vancomycin, clindamycin, and metronidazole were observed during the shortage; in contrast, a significant decrease in the use of ceftriaxone took place. No change in the rate of VRE infection was observed from before to during the piperacillin-tazobactam shortage. However, a paradoxical 47% decrease in the rate of C. difficile colitis was documented during the shortage. Subsequent multivariate analyses suggested the reduced use of ceftriaxone and increased use of levofloxacin, but not the reduced use of piperacillin-tazobactam, correlated with the decreased rate of C. difficile infections. The piperacillin-tazobactam shortage was associated with...Continue Reading

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Citations

Apr 25, 2014·Gastroenterology Report·Xinhua Chen, J Thomas Lamont
Nov 30, 2011·Antimicrobial Agents and Chemotherapy·C Plüss-SuardG Zanetti
Jan 25, 2013·World Journal of Gastroenterology : WJG·Cristian Hernández-RochaManuel Alvarez-Lobos
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Feb 25, 2009·Expert Opinion on Drug Metabolism & Toxicology·Maria F Wolf, Arne Simon
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Sep 26, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hsiao-Ju LinWen-Chien Ko
May 22, 2009·Gastroenterology·Daniel A Leffler, J Thomas Lamont
Jun 7, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Milena M GriffithMarc H Scheetz
May 20, 2015·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H HabayebS Van de Velde
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May 6, 2019·PloS One·Jonathan Minh PhuongRebekah Moles

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