Impact of a scientific presentation on community treatment patterns for primary breast cancer

Journal of the National Cancer Institute
Sharon H GiordanoJames S Goodwin

Abstract

The publication of results from randomized clinical trials can have a dramatic effect on treatment patterns, but the impact of oral presentations at national scientific meetings is unknown. We investigated the temporal association between the oral presentation of the results from the Cancer and Leukemia Group B (CALGB) Study 9344 at the May 1998 meeting of the American Society of Clinical Oncology, which showed that paclitaxel improves survival of women with lymph node-positive breast cancer, and use of taxane chemotherapy for breast cancer. We studied chemotherapy use in 3341 women identified through the Surveillance, Epidemiology, and End Results-Medicare database who were diagnosed with stage I-III breast cancer in 1994-1999 at age 65 years or older and received adjuvant chemotherapy, as identified through claims data, within 1 year of diagnosis. We assessed the temporal association between the CALBG presentation and taxane use with piecewise regression analysis. Multivariable logistic regression analysis was used to determine which patient characteristics were associated with taxane use. The use of taxanes increased substantially after the CALGB presentation, with absolute rates of taxane use of 5.2% before May 1998 and 23....Continue Reading

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Citations

Mar 30, 2007·Breast Cancer Research and Treatment·Erin J AielloAnn M Geiger
Jun 19, 2013·AJOB Primary Research·John LynchJoel Tsevat
Mar 16, 2006·Journal of the National Cancer Institute·Steven Woloshin, Lisa M Schwartz
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